If on an anti platelet type blood thinner, no problem. If on a vitamin K antagonist (VKA), as was Susan, K2 blocks the VKA and vice versa.by PC, MD - GENERAL HEALTH FORUM
Sorry to hear about your recurring problem with the unwanted visitor. I presume that you have symptoms other than cardiac that might be due to magnesium deficiency and for which you take magnesium citrate. Vitamin B6 is a required cofactor for about 120 enzymatic reactions that require magnesium (that we know of). If you feel up to it, you might consider trying 50 to 100 mg of water soluble vby PC, MD - GENERAL HEALTH FORUM
Yes, I wouldn’t take any chances. No K2 for youby PC, MD - GENERAL HEALTH FORUM
I would reduce it only if it made you feel uncomfortable. But make sure you’re taking your vitamin K2. If you were taking more than 5000 international units daily, I might reduce it slightly. Regarding magnesium supplements, one should look at the back of the bottle. If it says magnesium citrate or glycinate, … then the milligrams indicated are for the entire molecule not just the magnesiumby PC, MD - GENERAL HEALTH FORUM
Please furnish an article, if you can, documenting such an association. Actually the opposite is the case. If you’re MD considered your 46 too high, he has no credibility with me. Please visitby PC, MD - GENERAL HEALTH FORUM
If the 25 hydroxycholecalciferol level is below 50 ng/ml, then it is really a little low. I keep mine up around 80 ng/ml. Professor Wimalawansa advises 50 ng/ml. See the first article at If motivated and interested, look at his other articles there as well. Unfortunately he doesn’t mention magnesium which is absolutely critical. See figures 20, 21, 22 in my article atby PC, MD - GENERAL HEALTH FORUM
Hi Susan, If you’re taking 600 mg of elemental magnesium daily you don’t have to worry about a thing. I take about 700 mg of elemental magnesium, which is about perfect for me. You should consider increasing your daily intake of vitamin D from 2000 to about four or 5000. Fauci takes 6000 international units daily. The D increases both calcium and magnesium intestinal absorption . I combine thiby PC, MD - GENERAL HEALTH FORUM
In Mildred Seelig's great book MAGNESIUM DEFICIENCY IN THE PATHOGENESIS OF DISEASE several informative figures can be found at Specifically fig 12-2 shows that individuals on high calcium/vitamin D diets not only absorb less intestinal magnesium but also waste magnesium in their urine. Postmenopausal women are especially at risk for magnesium deficiency. This is probably why osteoporosisby PC, MD - GENERAL HEALTH FORUM
If your Ca/Mg ratio is high, you might even experience PACs when you take vitamin D. More than likely this is due to the consumption of magnesium in one with suboptimal stores. The consumption occurs during the production of active vitamin D. Magnesium is a required cofactor for hydroxylation (in the liver and kidney) of cholecalciferol to produce 1,25 dihydroxy cholecalciferol. Cholecalciferoby PC, MD - GENERAL HEALTH FORUM
Magnesium Treatment on Methylation Changes of Transmembrane Serine Protease 2 (TMPRSS2) Highlights * TMPRSS2 is essential for SARS-CoV-2 entry and prostate cancerprogression. * Higher expression of TMPRSS2relates to higher viral loads and worse outcomes. * TMPRSS2 affects COVID-19 severity by regulating the coagulation cascade. * Magnesium treatment increased 5-methylcytosine DNA methyby PC, MD - GENERAL HEALTH FORUM
Hi All, Ivermectin and hydroxychloroquine are anti malarials. SARS2 is a hybrid cross of malaria and SARS1. It Incorporates symptoms from both diseases and is why antimalarials are beneficial in COVID-19 patients suffering from malaria type symptoms. This would include hyper coagulable states, changes in taste and smell, and in general extra pulmonary symptoms, esp if you have no comorbiditby PC, MD - GENERAL HEALTH FORUM
This post is informational only. Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine NEJM article on Covid vaccine The Pfizer Covid 19 vaccine results were reported in the New England Journal of Medicine as 95% effective. This is relative benefit not absolute benefit. There were 40,000 volunteers in the study, ~20,000 receive the vaccine and ~20,000 received the placebo. In the placeboby PC, MD - GENERAL HEALTH FORUM
It is no coincidence that Ivermectin and hydroxychloroquine are powerful antimalarials. Ivermectin and malaria The preventative and therapeutic recommendations look a little light on the vitamin D.by PC, MD - GENERAL HEALTH FORUM
It is no coincidence that Ivermectin and hydroxychloroquine are powerful antimalarials. Ivermectin and malaria The preventative and therapeutic recommendations look a little light on the vitamin D.by PC, MD - GENERAL HEALTH FORUM
Hi Joe, Good question! Ivermectin for COVID-19 Treatment: Clinical Response at Quasi-Threshold Doses Via Hypothesized Alleviation of CD147-Mediated Vascular Occlusion Ivermectin and CD147by PC, MD - GENERAL HEALTH FORUM
I recently submitted a paper to a medical journal called Clinics in Medicine. It was peer reviewed without revision, accepted and scheduled for publication in 2021. I also posted it on an open access website. I thought some of you might be interested, although it’s a little technical. But you can skip over those parts and just read that which relates to vitamin D and magnesium. Whether you deciby PC, MD - GENERAL HEALTH FORUM
Thank you George you’re the man! In response to your intelligent comment I guess that only applies to an idevice. I knew there was an app, but kept forgetting to look. Mahaloby PC, MD - GENERAL HEALTH FORUM
Everybody knows about the connection between vitamin D deficiency and COVID-19 susceptibility and that it follows a latitude bias. The farther north or south of the equator one lives the greater the likelihood of vitamin D deficiency. However COVID-19 susceptibility also follows a bias with respect to longitude, which is even more significant. SARS-CoV-2 infections and COVID-19 mortalitiesby PC, MD - GENERAL HEALTH FORUM
I posted on this topic in the General Forum, but content may have been more appropriately posted here.by PC, MD - AFIBBERS FORUM
Addressing postmenopausal osteoporosis with vitamin D, calcium, and estrogen is guaranteed to make osteoporosis worse, unless one is serious about increasing dietary magnesium and/or supplementation. All one needs to know to understand the flow sheets is that vitamin D increases calcium and magnesium absorption, but calcium more than magnesium. Parathormone (PTH) responds to low blood calciumby PC, MD - GENERAL HEALTH FORUM
What's the target (how much to take), what form to take, when to take? BEWARE An acute increase in vitamin D, especially if in combination with calcium, can be problematic in the presence of low magnesium. Vitamin D facilitates the intestinal absorption of magnesium but especially calcium. The latter will give negative feedback inhibition to tone down the actions of vitamin D => even leby PC, MD - GENERAL HEALTH FORUM
A vitamin D deficiency was first recognized clinically in rickets (1920s). Many decades later magnesium deficient vitamin D resistant rickets was described. Magnesium-dependent vitamin-D-resistant rickets (1974) Now the spectrum of vitamin D deficient diseases has markedly expanded beyond rickets. Now compare the above with the expanding list of just magnesium deficient CNS diseases. Therby PC, MD - GENERAL HEALTH FORUM
Hi Betty Lou, I’m better with the written word not so much with the spoken one. That’s what this forum is for – back-and-forth. Just list your questions. I’m sure others have the same ones.by PC, MD - GENERAL HEALTH FORUM
I'll do my best, Ghost. But it’s a lot easier to hide behind big words. As you can see from the above diagram, no matter whether you get a precursor to the active form of vitamin D from your diet or from supplements, YOU CAN'T PRODUCE THE ACTIVE FORM IN THE ABSENCE OF MAGNESIUM. If you are Mg deficient you will develop muscle cramps (skeletal muscle), constipation (smooth muscle),by PC, MD - GENERAL HEALTH FORUM
And thank you, Mike, for the feedbackby PC, MD - AFIBBERS FORUM
Thank you, George Hi Pompon, You are ABSOLUTELY correct. LAF is highly complex. My post might help a few with the same flavor as mine. But remember Vitamin D and Mg are about more than just LAF, esp nowby PC, MD - AFIBBERS FORUM
I've been all over the waterfront on this. At first I posted that perhaps too much Vitamin D was bad for LAF. Then years later I reversed to the opposite view. Now I think that it depends on your biological individuality and how your physiology handles Ca. Here's an article that proposes D deficiency is the villain. The relationship between vitamin D and risk of atrial fibrillation:by PC, MD - AFIBBERS FORUM
My two most favorite and needed supplements. I’ve posted in the AF forum ad nauseum on magnesium and the same here on vitamin D. But repetition is the mother of learning. K should be in the top 10 too! But don't overlook omega 3s and K2, which are integral to magnesium and vitamin D physiology. The above and below images show that Mg is required for virtually every step to produceby PC, MD - GENERAL HEALTH FORUM
Aloha Dean Not sure how dark your skin pigmentation is, but it appears that darker skin can overwhelm the benefits of plentiful sunshine. The following is a study from the Philippines (use George's conversion above to get ng/ml => 35ng/ml is barely adequate; don't fear the 5000IU target) Here’s one from Indonesia (mild, ordinary, severe, critical) And here’s one from Europeby PC, MD - GENERAL HEALTH FORUM
Hi Wolfpack, Here’s a link to the complete article, not some journalist’s hype on it. A mechanistic model and therapeutic interventions for COVID-19 involving a RAS-mediated bradykinin storm Both ACE and ACE 2 are X-linked and you’re right this does explain some of the gender discrepancy for COVID-19. There’s a lot of good information in the article especially with respect to vitamin Dby PC, MD - GENERAL HEALTH FORUM