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Inhibition of NAPDH Oxidase 2 (NOX2) Prevents Oxidative Stress and Mitochondrial Abnormalities Caused by Saturated Fat in Cardiomyocytes Abstract Obesity and high saturated fat intake increase the risk of heart failure and arrhythmias. The molecular mechanisms are poorly understood. We hypothesized that physiologic levels of saturated fat could increase mitochondrial reactive oxygen speciby Marco - AFIBBERS FORUM
In the first study mice were fed a diet with 60% fat 20/20% Protein and Carbs. Fat used was Palm oil, which is pretty high is palmitic acid 44% of it, the rest is Oleic acid a MUFA. Second study always done with mice, again using Palm oil but this time cal from fat were 45%. I will dig a bit more, to understand if there is another study showing same results but this time with another typeby Marco - AFIBBERS FORUM
QuoteJoe Interesting - thanks for posting Marco! The left atria enlarges when in AF for extended periods but it also shrinks again when not in AF for several months (year?) At least that was the case with my atria after being in permanent AF for about 4 months in 2015 (about age 65) and since in paroxysmal with months in sinus in between (subjective and not monitored). Wonder if the fibroticby Marco - AFIBBERS FORUM
the success of Statin, Glucocorticoids and Fish oil in reducing atrial fibrosis, is likely related in reducing inflammation, especially at myocardium. If I'm understanding well this paper, IL‐1, IL‐6, TNFα, and MCP‐1 are upregulated during Afib, and are all causing remodeling of the heart by creating new fibrotic tissue. The goal may be to take something during Afib, that can decrease tby Marco - AFIBBERS FORUM
attaching the interesting parts, I think this is pretty good education material. Everyone can skip to the bold part and read that first George you going to like what they say here on Fish Oil. By the way, how can I tag people? What About Atrial Fibrillation? Atrial fibrosis is a hallmark of the structural cardiac remodeling that takes place in AF, causing an increase in the frequby Marco - AFIBBERS FORUM
QuoteGeorgeN What is your weight? I'm 190lbby Marco - AFIBBERS FORUM
an update after seeing an EP yesterday. He suggested Flecainide as a PIP, 300mg with no betablocker. I told him my concern of converting to flutters, but he confidently repeated few times not too worry about it, and that can only possibly happen when someone is on Flecainide every day. On one side, the cardiologist just gave me some Propranolol as a PIP, and he didn't want me to take Flecby Marco - AFIBBERS FORUM
QuoteGeorgeN If your BP is normally low, be careful of Propranolol (or any BP med). My daughter's father in law was recently prescribed a beta blocker for afib and he passed out due to low BP, fell and cracked some vertebrae. This may not be an issue for you, especially in afib, but just be aware. I think your issue with the quote above is that the ending Some breathing techniques aby Marco - AFIBBERS FORUM
I just realized the cardiologist gave me a RX for Propanolol as a PIP, not sure the dose yet, I will pick it up at the pharmacy once is ready.by Marco - AFIBBERS FORUM
QuoteGeorgeN. The number used to be 48 hours, but I think new data suggest the period when the risk starts is much shorter (I don't have the reference on this). Aspirin is not a great blood thinner. What is your CHA2DS2–VASc score? If more than 1, you should have a prescription for an oral anticoagulant like Eliquis or Xarelto, either to take all the time (as directed by doc) or to starby Marco - AFIBBERS FORUM
QuoteGeorgeN Marco, how long do your episodes take to convert on their own? I ask because my philosophy has always been to limit my time in afib as much as possible as "afib begets afib." not quiet sure what I'm doing with the quote response but I'm trying again: "the 3 times this happened, it took me 48 hours, or about 24 hours after being in the hospitaby Marco - AFIBBERS FORUM
thanks everyone for the adviseby Marco - AFIBBERS FORUM
QuoteGeorgeN Marco, how long do your episodes take to convert on their own? I ask because my philosophy has always been to limit my time in afib as much as possible as "afib begets afib." the 3 times this happened, it took me 48 hours, or about 24 hours after being in the hospital on the IV Ca channel blocker. However, from what I read in the forum, I understand this trendby Marco - AFIBBERS FORUM
well, I'm not sure I was fully happy with my cardiologist appointment today. Happy as in my stress test I scored above average, holter monitor showed some irregular heart beats, but according to cardiologist "nothing to worry about it", my echo did showed some mild LVH, but that's not a news as I have seen that in earlier years also, so we talked about controlling my BP. Oby Marco - AFIBBERS FORUM
QuoteCarey thanks. We do need a tiny bit of fluoride, but not too much. Too much Fluoride will almost certainly interact with the absorption of two very important mineral such as Magnesium and Iodine. Hopefully Flecainide has just a tiny bit in it I understand, but you should also understand that humans evolved over millions of years drinking water that contained high levels of fluoride. I tby Marco - AFIBBERS FORUM
QuoteCarey I don't know the chemical composition of flecainide and propafenone, but they almost certainly haven't changed. Changing the chemical formula would create a new drug, which means new clinical trials and new FDA approval. That's millions of dollars and years of time, so it didn't happen. You know that virtually all water and a gazillion other things you consume evby Marco - AFIBBERS FORUM
QuoteGeorgeN I have seen in some older posts that Flecainide contains Fluoride, is that still the case as today? does Propapenone contain Fluoride as well? Other than the Fluoride that I would prefer to avoid, being paroxysmal afibber, would one be better than the other one? Propafenone: C21H27NO3 Flecainide: C17H20F6N2O3 Here is the 2004 paper about PIP flecainide & propafenone.by Marco - AFIBBERS FORUM
I'm going to see my cardiologist tomorrow to see the results of my echo, holter monitor and stress test. He already mentioned the PIP at the first visit and we would discuss it on this follow up visit. I have seen in some older posts that Flecainide contains Fluoride, is that still the case as today? does Propapenone contain Fluoride as well? Other than the Fluoride that I would preferby Marco - AFIBBERS FORUM
QuoteGeorgeN "The BPC 157 therapy as antiarrhythmic agent follows the evidence that NO is commonly proposed as an endogenous cardioprotectant antifibrillatory factor [64,65] and that BPC 157 might modulate NO-effects (for review, see, i.e., [60]), and thereby might have a consistently strong beneficial effect against various arrhythmias and various agents and procedures that might produce arby Marco - AFIBBERS FORUM
All of the studies were done in rats, if they replicate to humans, this will be quiet awesome. BCP-157 seems to have an anti arrhythmic effect. I suggest to take a look at table n.3 in the studyby Marco - AFIBBERS FORUM
QuoteGeorgeN In the present study, the therapy effects and partly mechanisms were investigated. AF animal model was established by intravenous administered with the mixture of acetylcholine (Ach) and CaCl2 (66 μg/mL + 10 mg/mL) (i.v.) for 7 days. The actions of taurine (99 mg/kg∙d, introgastric administration) on the levels of Hs-CRP, IL-6, TNF-α, MMP-9, AngII, the extent of the fibrosis and ulby Marco - AFIBBERS FORUM
QuoteJackie Yes - Marco... Thanks for these. Important to know about the benefits of Taurine and glad to see you referencing these studies. About 20 years ago, I offered a post on this topic... and since then, many reports have been published. Here's the original.... plus more in the archives. Jackie I really enjoyed reading this paper. Lots of the info seems in line with whaby Marco - AFIBBERS FORUM
QuoteJackie Yes - Marco... Thanks for these. Important to know about the benefits of Taurine and glad to see you referencing these studies. About 20 years ago, I offered a post on this topic... and since then, many reports have been published. Here's the original.... plus more in the archives. Jackie thank you Jackie. If I find any more recent data on Taurine I will post it hby Marco - AFIBBERS FORUM
This is an interesting video where Harry Serpanos, big proponent of Taurine supplementation, mention he used 20gr of taurine to reduce fibrosis in his body, as he had a mini heart attack. He claims, most people all the need is 2 to 6gr of supplemental Taurine, more if there is an issue. Has anyone in the forum experimented with high dose Taurine in order to reverse atrial fibrosis? Video worthby Marco - AFIBBERS FORUM
More on Taurine. However, study was done in rats: Taurine Reverses Atrial Structural Remodeling in Ach-Cacl2 Induced Atrial Fibrillation Rats Qunhui Yang 1, Gaofeng Wu 1, Limei Han 1, Ying Feng 1, Shumei Lin 1, Qiufeng Lv 1, Jiancheng Yang 1, Jianmin Hu 2 Affiliations expand PMID: 28849503 DOI: 10.1007/978-94-024-1079-2_65 Abstract Taurine has been reported to have anti-arrhythmby Marco - AFIBBERS FORUM
Summary and prospect Atrial fibrillation (AF) is the most common malignant arrhythmia in clinic. It is estimated that more than 33 million people worldwide are affected by AF (Christophersen et al., 2017). In recent years, China has become the country with the largest number of patients with AF in the world, and the prevalence of AF will further increase with the aging of the population in Cby Marco - AFIBBERS FORUM
QuotePavanPharter I also want to point out that, I believe nobody knows, what would be the mechanism of which fish oil could cause afib. After all, real food is also safer than food supplements. However, fatty fish such as salmon, are full of mercury. . Nope. Fresh wild caught salmon is one of the LOWEST of commercial fish, You'd have to eat 53lbs a week to be at risk. Tuna hby Marco - AFIBBERS FORUM
QuoteGeorgeN I just wanted to make a comment on study n2, the last at the bottom. Quintile n.5, the group who took the more marine omega 3 and had more Afib episodes, also took more alcohol and it was the group who also had the higher blood pressure, unless I'm not reading the study properly. . In the study, they said they adjusted for BP & alcohol. Here are my issues: 1. Thby Marco - AFIBBERS FORUM
QuotePavanPharter What to believe? In RCTs examining cardiovascular outcomes, marine ɷ-3 supplementation was associated with an increased risk of AF. The risk appeared to be greater in trials testing >1 g/d. We found a U-shaped association between consumption of marine n-3 PUFA and risk of incident AF, with the lowest risk close to the median intake of total marine n-3 PUFA (0by Marco - AFIBBERS FORUM
Quotegloaming Thanks for posting, Marco. I love fish, but the missus don't. She'll eat it about once a week...IF...I cook it. It's the smell, and to a certain extent the taste that puts her off. So, supplements it is. you are welcomeby Marco - AFIBBERS FORUM