Michael Murray, ND, wrote about risks with PPIs in 2015 and 2016... many other functional nutrition medicine type physicians have also offered warnings based on the study observations. It's known that often the GERD issues come from inadequate nutrients that support producing one's own stomach acid. The second report indicates a potential association with hypomagnesia which would definitely be detrimental for afibbers.
Intro to Summary Report on PPI Side Effects dated 1/16/18....
Top Five Reasons NEVER to Take PPIs
Millions of doses of "acid blocking" proton pump inhibitor drugs are doled out every year, yet most doctors and their patients are completely oblivious to their unintended, adverse effects, which include increased risk for premature death.
Proton pump inhibitors are a type of drug commonly known as acid-blockers, whose primary purpose is to reduce the amount of gastric acid secreted in the stomach wall. Available with or without a prescription, acid-blockers are used to treat common disorders such as indigestion, heartburn, acid reflux, and various ulcers. These types of digestive disturbances are so common, proton pump inhibitors, or PPIs, were prescribed at nearly 270 million hospital trips made by adults via ambulance from 2006 to 2010.[1] The standard American diet of sugar-laden, highly-acidic processed foods, and the stress-filled lifestyle that accompanies it, make it easy to swallow the fact that PPIs are among the most highly prescribed drugs on the planet.
Economically, the boost these drugs represent to pharmaceutical companies cannot be overstated. With cumulative sales of more than $10 billion dollars annually, drugs like Nexium, Prilosec, Prevacid, and others, represent a significant chunk of Big Pharma’s profits.[2] Despite clinical research that shows an act as simple as drinking more water reduces stomach acid more than these drugs, and does so safely with no negative side effects, Big Pharma’s relationship with the corner doctor’s office too often prevents these basic self-help practices from being disseminated.
PPIs work by raising stomach pH above normal range to inhibit secretion of pepsin, a digestive enzyme that can be irritating to stomach lining. While this action may provide temporary feelings of relief, it effectively blocks secretion of normal, healthy enzymes, impairing the body’s digestive function over the long-term. Lack of adequate stomach secretions can also expose us to harmful molds, viruses, and bacteria that may be present in our food.
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www.greenmedinfo.com]
6/16/15
Acid-Blocking Drugs Increase Heart Disease Risk
Introduction
Prproton-pump inhibitorsoton-pump inhibitors (PPIs) are a group of drugs whose main action is blocking the secretion of gastric acid. They are dominant medical treatment of peptic ulcers, gastroesophageal reflux disease (GERD), and indigestion. Popular examples include Nexium, Prilosec, Protonix, Prevacid, and Aciphex. Use of these powerful antacids is associated with an increased risk for osteoporosis, heart arrhythmias, intestinal infections, bacterial pneumonia, and multiple nutrient deficiencies. A new study from Stanford University adds another issue with these drugs – they double the risk of dying from a heart attack or stroke.
Background Data:
PPIs will typically raise the gastric pH above the normal range of 3.5, effectively inhibiting the action of pepsin – an enzyme involved in protein digestion that can be irritating to the stomach. Although raising the pH can reduce symptoms, it also substantially blocks a normal body process. The manufacture and secretion of stomach acid is very important not only to the digestive process, but also because it is an important protective mechanism against infection. Stomach secretions can neutralize bacteria, viruses and molds before they can cause gastrointestinal infection.
As far as the digestive process, stomach acid is not only important in the initiation of protein digestion, it ionizes minerals and other nutrients for enhanced absorption; and without sufficient secretion of HCl in the stomach the pancreas does not get the signal to secrete its digestive enzymes.
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doctormurray.com]
Abstract Title:
The association between the use of proton pump inhibitors and the risk of hypomagnesemia: a systematic review and meta-analysis.
Abstract Source: PLoS One. 2014 ;9(11):e112558. Epub 2014 Nov 13. PMID: 25394217
Abstract Author(s): Chan Hyuk Park, Eun Hye Kim, Yun Ho Roh, Ha Yan Kim, Sang Kil Lee
Abstract:
BACKGROUND: Although many case reports have described patients with proton pump inhibitor (PPI)-induced hypomagnesemia, the impact of PPI use on hypomagnesemia has not been fully clarified through comparative studies. We aimed to evaluate the association between the use of PPI and the risk of developing hypomagnesemia by conducting a systematic review with meta-analysis.
METHODS: We conducted a systematic search of MEDLINE, EMBASE, and the Cochrane Library using the primary keywords" proton pump,""dexlansoprazole,""esomeprazole,""ilaprazole,""lansoprazole,""omeprazole,""pantoprazole,""rabeprazole,""hypomagnesemia,""hypomagnesaemia,"and"magnesium."Studies were included if they evaluated the association between PPI use and hypomagnesemia and reported relative risks or odds ratios or provided data for their estimation. Pooled odds ratios with 95% confidence intervals were calculated using the random effects model. Statistical heterogeneity was assessed with Cochran's Q test and I2 statistics.
RESULTS: Nine studies including 115,455 patients were analyzed. The median Newcastle-Ottawa quality score for the included studies was seven (range, 6-9). Among patients taking PPIs, the median proportion of patients with hypomagnesemia was 27.1% (range, 11.3-55.2%) across all included studies. Among patients not taking PPIs, the median proportion of patients with hypomagnesemia was 18.4% (range, 4.3-52.7%). On meta-analysis, pooled odds ratio for PPI use was found to be 1.775 (95% confidence interval 1.077-2.924). Significant heterogeneity was identified using Cochran's Q test (df = 7, P<0.001, I2 = 98.0%).
CONCLUSIONS: PPI use may increase the risk of hypomagnesemia. However, significant heterogeneity among the included studies prevented us from reaching a definitive conclusion.
Article Published Date : Dec 31, 2013
Just a few of many similar reports.... FYI.
Jackie