Is stroke inevitable? September 11, 2014 10:38AM |
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Re: Is stroke inevitable? September 11, 2014 01:29PM |
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Re: Is stroke inevitable? September 11, 2014 08:13PM |
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Quote
The Mayo researchers made the following important observations:
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1. The observed mortality rate among the afibbers over a 25-year period was substantially lower (15.9%) than the mortality expected in a group of age- and sex-matched white Minnesotans (32.5%).
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2. The incidence of ischemic stroke (cerebral infarction) in the afib group was no greater (0.5%/person-year) than in the general population. The researchers conclude that, This observation indicated that the pathophysiological mechanisms responsible for the development of a cerebrovascular event were unrelated to the continued presence of AF. In other words, LAF as such is not associated with an increased risk of stroke.
3. The volume of the left atrium (LAV) is an important indicator of the risk of adverse events such as stroke, heart attack (myocardial infarction), and congestive heart failure. A LAV (indexed for age and body mass) equal to or greater than 32 mL/m2 was associated with a 4.46-fold increase in the probability of experiencing an adverse event.
4. All cerebral infarctions occurred in participants whose LAV prior to the incident was greater than 32 mL/m2.
5. No correlation between age or the number of years afib had been present (duration) and LAV was observed; however, there was a highly significant correlation between persistent afib and enlarged LAV.
6. The average age at which a stroke occurred in the LAF group was 77 years, not significantly different from that observed in the general population.
7. Eighteen participants died during the study; 9 of cardiovascular disease, 4 of cancer, and 4 of a respiratory tract infection.
The researchers conclude that LAV is an important predictor of the likelihood that lone afibbers will suffer adverse events (stroke, heart attack, etc) during their lifetime. It is far more important than age and left ventricular ejection fraction. They suggest that only afibbers with a LAV less than 32 mL/m2 should be classified as lone. These afibbers had a benign clinical course during follow-up, while afibbers with an elevated LAV at diagnosis or later during follow-up experienced adverse events.
Re: Is stroke inevitable? September 11, 2014 10:47PM |
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Re: Is stroke inevitable? September 12, 2014 09:38AM |
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Re: Is stroke inevitable? September 12, 2014 03:47PM |
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Re: Is stroke inevitable? September 12, 2014 06:40PM |
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Re: Is stroke inevitable? September 12, 2014 10:11PM |
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Re: Is stroke inevitable? September 13, 2014 11:14AM |
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Re: Is stroke inevitable? October 03, 2014 07:04AM |
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