Reversing afib risk factors May 15, 2014 03:18PM |
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Background: Previous work from the Adelaide researchers has demonstrated the causative role of typical cardiovascular risk factors (obesity, high blood pressure, diabetes, smoking, alcohol, sleep apnea, etc) in promoting the substrate for atrial fibrillation. Last year at the Heart Rhythm Society 2013 Scientific Sessions, this group presented data showing that weight loss (in obese sheep) resulted in favorable structural and electrical properties of the atria[2]. Most notably, there was a reduction in interstitial fibrosis. They then demonstrated similar findings in humans. In this study [3], which was published in the Journal of the American Medical Association, they selected overweight AF patients on the waiting list for ablation and randomized them to either a physician-led lifestyle-intervention group or standard care. Both groups lost weight and improved on measures of overall health, but those in the aggressive-intervention group improved much more. Just like the sheep, humans who lost weight enjoyed shrinking LA volumes and striking drops in AF burden, with 30% of patients avoiding AF ablatio
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