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for those on statins...
Posted by Dick
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Dick
for those on statins... June 28, 2010 05:29AM |
This article caught my eye not only so much for its positive findings on a small sample of patients on the effects of eprotirome, a liver selective thyroid hormone receptor agonist , but for the acknowledgment that statin side effects are a problem:
"It's often not so much that the statin didn't work, but that at least a quarter of statin-treated patients have side effects that limit their use, usually myalgias like muscle pain or stiffness," he said. "I do think there is a large unmet need in a few groups of patients, such as patients who don't tolerate statins, patients who tolerate statins but aren't able to get to goal, patients who have not only elevated LDL cholesterol but also high triglycerides, and finally, patients with elevations in lipoprotein(a)."
[www.theheart.org]
It makes me a bit nervous to see the list of side effects that might be expected but weren't found from this type of drug, including arrhythmia. The authors admit that the study only covered 12 weeks ....
-- Dick
"It's often not so much that the statin didn't work, but that at least a quarter of statin-treated patients have side effects that limit their use, usually myalgias like muscle pain or stiffness," he said. "I do think there is a large unmet need in a few groups of patients, such as patients who don't tolerate statins, patients who tolerate statins but aren't able to get to goal, patients who have not only elevated LDL cholesterol but also high triglycerides, and finally, patients with elevations in lipoprotein(a)."
[www.theheart.org]
It makes me a bit nervous to see the list of side effects that might be expected but weren't found from this type of drug, including arrhythmia. The authors admit that the study only covered 12 weeks ....
-- Dick
|
researcher
Re: for those on statins... June 28, 2010 06:02AM |
i have been on statins for nearly 20 years now. My reduction in LDL is around 45%, HDL is good because I regularly exercise, triglycerides was never a problem. I have had myalgia with Lipitor. I recovered quickly after I switched to Vytorin. The thinking on statins is still in a state of flux after 20 years. I tried Niacin before statins and I had intolerable side effects such as sweating and flushing right in the middle of business meetings.
|
Re: for those on statins... June 29, 2010 11:50AM |
Registered: 6 years ago Posts: 18,882 |
Dick
and anyone else
regarding the use of statin drugs or any other substance that blocks cholesterol production, the following may be of interest. Its certainly important information as typically, the public doesnt understand what cholesterol is and how it performs crucial functions in the body.
Another awareness post.
What really is the role of cholesterol in the body?
I recently took notes during a teleconference about Cholesterol Myths by Jeremy Webster, DC who practices functional medicine. Dr. Websters observations follow right along with the information provided in the book by well-known well-known physician, researcher, Uffe Ravnskoff, MD, PhD, and at the website referenced below. Anyone interested in interested in learning more about the myths and the facts will find an abundance of documentation that supports what Dr. Webster offered in the teleconference.
Critical nutrient pathways are blocked by statin-type drugs including CoQ10 which should be of interest to afibbers since CoQ becomes vital for the production of energy in heart cells. Its not difficult to see how blocking cholesterol and interfering with the role cholesterol plays in the body can and does cause far-reaching symptoms and serous consequences..
Following is a relevant segment of my notes.
Jackie
Cholesterol myths
Good cholesterol/bad cholesterol is a misnomer.
LDL and HDL are lipoproteins not really cholesterol at all and their job is to help transport cholesterol and other lipids like triglycerides through the blood stream. Without LDL or HDL attaching to cholesterol, it is not able to go where it wants to go or is needed. The purpose of LDL is to mobilize cholesterol from the source primarily the liver out to a site where it is needed . ie, if there is tissue damage somewhere in the body, then LDL binds to cholesterol and transports it to that site where cholesterol aids in the repair process like in muscle tissue or even an artery.
HDL helps mobilize cholesterol in the blood also but is the reverse of LDL HDL takes the cholesterol from the site of damage once the repair is done and is shuttled back to the liver so cholesterol can be recycled or used for other functions, such as converting into bile .
So a supply of both lipoproteins is important when needed.
Cholesterol is one of the most important molecules in the body . right up there with vitamin C and glutathione.
There are observations that people with higher cholesterol have higher rates of heart disease; and, it is true in some cases but the important question is what is the cause and whats the effect?
If free radicals are doing a lot of damage in the cardiovascular system, then the body is going to respond to repair that damage and it will respond with LDL. This would mean then, if you have that much free radical damage, then you are at a higher risk for CV disease. The LDL is just responding to the damaging process but it doesnt mean that the LDL is causing the disease.
Bile from the liver mobilizes toxins and after a meal, it helps break down fats so the essential fats can be absorbed along with fat-soluble vitamins( A, D, E and K ) which are crucial to our healthespecially in terms of CV risk. Bile cant exist without cholesterol and without bile, essential nutrients to help fight CV disease wont be absorbed. So obviously, cholesterol is extremely important. So one could say cholesterol helps fight CV disease rather than cause it.
Cholesterol is the building block of fat-soluble vitamin D. There is a specific cholesterol molecule in the skin (7-dehydro cholesterol) that is activated by UV light hitting the skin. It stimulates the production of vitamin D3 (cholecalciferol). Without cholesterol, it is impossible to have that reaction. It converts into 25 hydroxy vitamin D in the liver and the kidneys convert it down to calciferol, 1-25 dihydroxyvitamin D. If cholesterol levels are too low, that process wont even get started.
We know that vitamin D has an important link to osteoporosis risk reduction because of the calcium formation factor. Additionally, cancer rates are reduced, auto immunity is reduced and CV risk is reduced as well. For instance insulin resistance is affected by vitamin D levels. Low D levels increases risk for insulin resistance. Insulin resistance is a greater risk for inflammation. Inflammation is a key factor in CV disease.
When you want to consider something that is correlated to any type of disease its inflammation. You can name your favorite disease of aging . osteoporosis, CV disease, diabetes, cancer they all have a connection to the inflammatory process. We know vitamin D is crucial to modulating that inflammatory process.
Calcium absorption might also be a way vitamin D would help CV disease because calcium is an electrolyte and the lack of calcium control can influence rate and rhythm control in arrhythmias. So remember, without cholesterol, there is no vitamin D.
Cholesterol is so important that in the case of vegetarians not eating meat sources of fat, the body just goes ahead and makes cholesterol anyway. When we eat less cholesterol, we tend to make more. When we eat more cholesterol, we tend to make less. So dietary intake doesnt really affect levels of cholesterol that much.
Cholesterol and brain function. Every cell in our body has a membrane. Without cholesterol, a membrane wouldnt be sustainable in a human being. Cells that have no membrane have a cell wall ie, bacteria or plant. In humans, the cholesterol imbeds itself between the phospholipids bi-layer and gives the stability and rigidity to the bi-layer. Cholesterol is important to the structure of the brain as well as all the other cells in our body...If we didnt have cellular structure, wed be like a blob.
In the brain, cholesterol is very rich in the myelin sheath the insulating cells that wrap around the neurons; and without that, we cant transmit neuronal action at all. The impulses would be slow rather than lightning fast as in the brain. Low cholesterol levels can affect the ability to make myelin ( multiple sclerosis) ie, the stripping of the myelin sheath. So we dont want to take away the building block of something so important as that myelin molecule.
Serotonin neurotransmitter in the brain which helps stabilize mood, reduces sugar and carbohydrate craving, allows a normal threshold for pain. Without normal levels of cholesterol, serotonin cant be absorbed into the brain. The serotonin cant cross the blood brain barrier and the brain becomes serotonin deficient with symptoms of depression, pain, sugar craving and much more.
Science Daily October 2009, found that brain cells with adequate cholesterol levels can form more of dopamine-producing nerve cells in the brain if you have adequate levels as opposed to lower levels are unable to produce as many of the dopamine nerve cells. The cells lie in the substantia nigra of the brain and are implicated in Parkinsons disease. So low cholesterol may be highly related to Parkinsons.
Long term statin users muscle pain is a common symptom. Also, people seem to be in a fog; they cant think well because they cant produce the dopamine because of low cholesterol. This doesnt mean everyone with low dopamine will get the classic Parkinsons tremor. What it means is you cant initiate things in your brain. You wont be able to initiate movement and also wont be able to initiate cognition so thought patterns will be extremely slow if you cant produce dopamine properly. The loops in the brain just shut down and cant get started. You cant get up and go physically or mentally.
This study also said those with the best cholesterol levels in their brain have a reduced tendency of the stem cells to slow uncontrolled growth. Interesting because many think all cancer comes from stem cells rather than fully matured cells. This relates to long term use of statin drugs because what they are finding now is that cancer rates go up when you take a statin for an extended period of time.
[Science Daily also reported in May 2010 - Some Statins Have Unintended Effects and Warrant Closer Monitoring, Study Finds]
Sex steroids/hormones
Just like cholesterol is the building block for bile and vitamin D, it is also the building block of the sex hormones: pregnenolone, testosterone, all estrogens, progesterone, DHEA all are made from cholesterol.
Corticosteroid hormones (cortisol) are also derived from cholesterol and will be inhibited. They have crucial functions in the body including fertility issues. These are the chemicals our bodies run on and if we depress the building blocks of these hormones and then think there will be no serious impact on our health is not a reasonable assumption. This would include fertility issues and breast feeding. Breast milk is extremely high in cholesterol because the baby needs that cholesterol to build its brain cells, membranes and the other great functions weve mentioned. If not breast feeding, its important to give the baby something that is a rich source of cholesterol or they develop mentally much slower without plenty of cholesterol. Goats milk is an ideal substitute for breast milk. Soy no-- and cows milk not quite as bad as soy.
Side effects are much more serious than muscle pain.
Increased cancer rates are very real as is depression.
Increased congestive heart failure because of the suppression of Coenzyme Q10.
Its like taking a drug to reduce glutathione levels in your body or vitamin C levels. Very serious things would happen. And drugs that reduce cholesterol are just as scary and dangerous.
The worst side effect of statins suppressing the production of Coenzyme Q10.
How do statins suppress the production of Coenzyme Q10?
A statin is an HMG-CoA reductase inhibitor.
The HMG-CoA reductase is an enzyme that leads to the conversion of or the creation of Coenzyme Q10 and then a few steps later, cholesterol is produced from this pathway. So statin drugs start all the way at the top and knock out the enzyme so you dont get the production of cholesterol AND you also wont get production of Coenzyme Q10.
Coenzyme Q10, along with B vitamins and some minerals is probably the most important nutrient that allows our body to make energy.
By energy, this means not just pep, its cash or currency for the cells. So if you cant make energy in the cells, the cell cant function, repair itself, detoxify itself and the cell basically becomes dysfunctional. So a muscle cell cant contract, brain cells cant fire so you cant think, heart cells cant contract; liver cant detoxify, nothing can do its job when you cant make energy. The body just shuts down. [side comment: the energy referenced is ATP and its all about ATP!]
If you push CoQ10 low enough, you are contributing to the exact things we are trying to prevent by using the statin type drugs. Taking something to prevent the risk of heart disease, actually promotes a different type of heart disease and probably at a greater rate than lowering cholesterol prevents heart disease.
As mentioned in the book Cholesterol Myths by Uffe Ravnskoff, MD, PhD looking at the various stain studies yes the drugs do lower cholesterol but what really should be the goal is not to lower cholesterol but reduce cardiovascular disease and to reduce death and statins dont seem to do those very well at all. In a lot of cases, depending on the population, death rates and CV disease actually increase in those that take statin drugs.
So you die with lower cholesterol.
Mercury and cholesterol
Mercury toxicity may be one of the reasons why people have elevated cholesterol of around 250-260 something going on, they are probably at high risk of CV disease, something is damaging their body -causing oxidative stress and they are releasing cholesterol in order to repair tissue damage, reduce inflammation, and cholesterol actually has antioxidant properties so its being released as a preventive mechanism.
With mercury as a toxic metal probably the worst it increases inflammation, increase free radicals, and destroys the cell .and all of these things will trigger the release of cholesterol in an attempt to reverse the damage. So the link is pretty easy to make.
He observes that people with large numbers of mercury-amalgam fillings tend to have a high anxiety level. Anxiety leads to excess cortisol production, fight or flight sympathetic response, so if your body is demanding cortisol... where are you going to get it? You have to release cholesterol in order to make cortisol. So this is the link to increased risk of heart disease and increased cholesterol levels.
Toxic metals are related to just about every neurological disease
Unless lowering cholesterol becomes the last resort, clinically, its probably not the best thing to do.
The cholesterol monitoring industry is a $100 billion including the diagnosing, treating, monitoring and the drug itself, so it would be very difficult change thoughts on this, obviously.
End of selected teleconference notes.
Jeremy Webster, DC
Dr. Jeremy S. Webster received his Bachelors in Electrical Engineering from Oklahoma State University and then attended Parker College in Dallas, TX where he received his Doctorate of Chiropractic. Dr. Webster has post-doctoral training in Neurology from the prestigious Carrick Institute for Graduate Studies. He has specialized training in vestibular rehabilitation which deals with those with vertigo and dizziness. He is currently seeking a diplomate degree in Chiropractic Neurology. Dr. Webster has lectured on the interactions of nutrition and the nervous system to health professionals as well as the public.
Dr. Webster has geared his studies towards the treatment of physiologically and nutritionally based problems that adversely affect health and ultimately prevent weight loss. Nutritional deficiencies, toxicities, and poor neurological function are all assessed in his office in Dallas, Texas.
[www.ravnskov.nu]
[www.thincs.org]
7-dehydrocholesterol reductase
[ghr.nlm.nih.gov]
[www.sciencedaily.com]
[www.sciencedaily.com]
Some Statins Have Unintended Effects and Warrant Closer Monitoring, Study Finds May 2010
(these are rough notes; sorry if there are typos )
Another awareness post.
What really is the role of cholesterol in the body?
I recently took notes during a teleconference about Cholesterol Myths by Jeremy Webster, DC who practices functional medicine. Dr. Websters observations follow right along with the information provided in the book by well-known well-known physician, researcher, Uffe Ravnskoff, MD, PhD, and at the website referenced below. Anyone interested in interested in learning more about the myths and the facts will find an abundance of documentation that supports what Dr. Webster offered in the teleconference.
Critical nutrient pathways are blocked by statin-type drugs including CoQ10 which should be of interest to afibbers since CoQ becomes vital for the production of energy in heart cells. Its not difficult to see how blocking cholesterol and interfering with the role cholesterol plays in the body can and does cause far-reaching symptoms and serous consequences..
Following is a relevant segment of my notes.
Jackie
Cholesterol myths
Good cholesterol/bad cholesterol is a misnomer.
LDL and HDL are lipoproteins not really cholesterol at all and their job is to help transport cholesterol and other lipids like triglycerides through the blood stream. Without LDL or HDL attaching to cholesterol, it is not able to go where it wants to go or is needed. The purpose of LDL is to mobilize cholesterol from the source primarily the liver out to a site where it is needed . ie, if there is tissue damage somewhere in the body, then LDL binds to cholesterol and transports it to that site where cholesterol aids in the repair process like in muscle tissue or even an artery.
HDL helps mobilize cholesterol in the blood also but is the reverse of LDL HDL takes the cholesterol from the site of damage once the repair is done and is shuttled back to the liver so cholesterol can be recycled or used for other functions, such as converting into bile .
So a supply of both lipoproteins is important when needed.
Cholesterol is one of the most important molecules in the body . right up there with vitamin C and glutathione.
There are observations that people with higher cholesterol have higher rates of heart disease; and, it is true in some cases but the important question is what is the cause and whats the effect?
If free radicals are doing a lot of damage in the cardiovascular system, then the body is going to respond to repair that damage and it will respond with LDL. This would mean then, if you have that much free radical damage, then you are at a higher risk for CV disease. The LDL is just responding to the damaging process but it doesnt mean that the LDL is causing the disease.
Bile from the liver mobilizes toxins and after a meal, it helps break down fats so the essential fats can be absorbed along with fat-soluble vitamins( A, D, E and K ) which are crucial to our healthespecially in terms of CV risk. Bile cant exist without cholesterol and without bile, essential nutrients to help fight CV disease wont be absorbed. So obviously, cholesterol is extremely important. So one could say cholesterol helps fight CV disease rather than cause it.
Cholesterol is the building block of fat-soluble vitamin D. There is a specific cholesterol molecule in the skin (7-dehydro cholesterol) that is activated by UV light hitting the skin. It stimulates the production of vitamin D3 (cholecalciferol). Without cholesterol, it is impossible to have that reaction. It converts into 25 hydroxy vitamin D in the liver and the kidneys convert it down to calciferol, 1-25 dihydroxyvitamin D. If cholesterol levels are too low, that process wont even get started.
We know that vitamin D has an important link to osteoporosis risk reduction because of the calcium formation factor. Additionally, cancer rates are reduced, auto immunity is reduced and CV risk is reduced as well. For instance insulin resistance is affected by vitamin D levels. Low D levels increases risk for insulin resistance. Insulin resistance is a greater risk for inflammation. Inflammation is a key factor in CV disease.
When you want to consider something that is correlated to any type of disease its inflammation. You can name your favorite disease of aging . osteoporosis, CV disease, diabetes, cancer they all have a connection to the inflammatory process. We know vitamin D is crucial to modulating that inflammatory process.
Calcium absorption might also be a way vitamin D would help CV disease because calcium is an electrolyte and the lack of calcium control can influence rate and rhythm control in arrhythmias. So remember, without cholesterol, there is no vitamin D.
Cholesterol is so important that in the case of vegetarians not eating meat sources of fat, the body just goes ahead and makes cholesterol anyway. When we eat less cholesterol, we tend to make more. When we eat more cholesterol, we tend to make less. So dietary intake doesnt really affect levels of cholesterol that much.
Cholesterol and brain function. Every cell in our body has a membrane. Without cholesterol, a membrane wouldnt be sustainable in a human being. Cells that have no membrane have a cell wall ie, bacteria or plant. In humans, the cholesterol imbeds itself between the phospholipids bi-layer and gives the stability and rigidity to the bi-layer. Cholesterol is important to the structure of the brain as well as all the other cells in our body...If we didnt have cellular structure, wed be like a blob.
In the brain, cholesterol is very rich in the myelin sheath the insulating cells that wrap around the neurons; and without that, we cant transmit neuronal action at all. The impulses would be slow rather than lightning fast as in the brain. Low cholesterol levels can affect the ability to make myelin ( multiple sclerosis) ie, the stripping of the myelin sheath. So we dont want to take away the building block of something so important as that myelin molecule.
Serotonin neurotransmitter in the brain which helps stabilize mood, reduces sugar and carbohydrate craving, allows a normal threshold for pain. Without normal levels of cholesterol, serotonin cant be absorbed into the brain. The serotonin cant cross the blood brain barrier and the brain becomes serotonin deficient with symptoms of depression, pain, sugar craving and much more.
Science Daily October 2009, found that brain cells with adequate cholesterol levels can form more of dopamine-producing nerve cells in the brain if you have adequate levels as opposed to lower levels are unable to produce as many of the dopamine nerve cells. The cells lie in the substantia nigra of the brain and are implicated in Parkinsons disease. So low cholesterol may be highly related to Parkinsons.
Long term statin users muscle pain is a common symptom. Also, people seem to be in a fog; they cant think well because they cant produce the dopamine because of low cholesterol. This doesnt mean everyone with low dopamine will get the classic Parkinsons tremor. What it means is you cant initiate things in your brain. You wont be able to initiate movement and also wont be able to initiate cognition so thought patterns will be extremely slow if you cant produce dopamine properly. The loops in the brain just shut down and cant get started. You cant get up and go physically or mentally.
This study also said those with the best cholesterol levels in their brain have a reduced tendency of the stem cells to slow uncontrolled growth. Interesting because many think all cancer comes from stem cells rather than fully matured cells. This relates to long term use of statin drugs because what they are finding now is that cancer rates go up when you take a statin for an extended period of time.
[Science Daily also reported in May 2010 - Some Statins Have Unintended Effects and Warrant Closer Monitoring, Study Finds]
Sex steroids/hormones
Just like cholesterol is the building block for bile and vitamin D, it is also the building block of the sex hormones: pregnenolone, testosterone, all estrogens, progesterone, DHEA all are made from cholesterol.
Corticosteroid hormones (cortisol) are also derived from cholesterol and will be inhibited. They have crucial functions in the body including fertility issues. These are the chemicals our bodies run on and if we depress the building blocks of these hormones and then think there will be no serious impact on our health is not a reasonable assumption. This would include fertility issues and breast feeding. Breast milk is extremely high in cholesterol because the baby needs that cholesterol to build its brain cells, membranes and the other great functions weve mentioned. If not breast feeding, its important to give the baby something that is a rich source of cholesterol or they develop mentally much slower without plenty of cholesterol. Goats milk is an ideal substitute for breast milk. Soy no-- and cows milk not quite as bad as soy.
Side effects are much more serious than muscle pain.
Increased cancer rates are very real as is depression.
Increased congestive heart failure because of the suppression of Coenzyme Q10.
Its like taking a drug to reduce glutathione levels in your body or vitamin C levels. Very serious things would happen. And drugs that reduce cholesterol are just as scary and dangerous.
The worst side effect of statins suppressing the production of Coenzyme Q10.
How do statins suppress the production of Coenzyme Q10?
A statin is an HMG-CoA reductase inhibitor.
The HMG-CoA reductase is an enzyme that leads to the conversion of or the creation of Coenzyme Q10 and then a few steps later, cholesterol is produced from this pathway. So statin drugs start all the way at the top and knock out the enzyme so you dont get the production of cholesterol AND you also wont get production of Coenzyme Q10.
Coenzyme Q10, along with B vitamins and some minerals is probably the most important nutrient that allows our body to make energy.
By energy, this means not just pep, its cash or currency for the cells. So if you cant make energy in the cells, the cell cant function, repair itself, detoxify itself and the cell basically becomes dysfunctional. So a muscle cell cant contract, brain cells cant fire so you cant think, heart cells cant contract; liver cant detoxify, nothing can do its job when you cant make energy. The body just shuts down. [side comment: the energy referenced is ATP and its all about ATP!]
If you push CoQ10 low enough, you are contributing to the exact things we are trying to prevent by using the statin type drugs. Taking something to prevent the risk of heart disease, actually promotes a different type of heart disease and probably at a greater rate than lowering cholesterol prevents heart disease.
As mentioned in the book Cholesterol Myths by Uffe Ravnskoff, MD, PhD looking at the various stain studies yes the drugs do lower cholesterol but what really should be the goal is not to lower cholesterol but reduce cardiovascular disease and to reduce death and statins dont seem to do those very well at all. In a lot of cases, depending on the population, death rates and CV disease actually increase in those that take statin drugs.
So you die with lower cholesterol.
Mercury and cholesterol
Mercury toxicity may be one of the reasons why people have elevated cholesterol of around 250-260 something going on, they are probably at high risk of CV disease, something is damaging their body -causing oxidative stress and they are releasing cholesterol in order to repair tissue damage, reduce inflammation, and cholesterol actually has antioxidant properties so its being released as a preventive mechanism.
With mercury as a toxic metal probably the worst it increases inflammation, increase free radicals, and destroys the cell .and all of these things will trigger the release of cholesterol in an attempt to reverse the damage. So the link is pretty easy to make.
He observes that people with large numbers of mercury-amalgam fillings tend to have a high anxiety level. Anxiety leads to excess cortisol production, fight or flight sympathetic response, so if your body is demanding cortisol... where are you going to get it? You have to release cholesterol in order to make cortisol. So this is the link to increased risk of heart disease and increased cholesterol levels.
Toxic metals are related to just about every neurological disease
Unless lowering cholesterol becomes the last resort, clinically, its probably not the best thing to do.
The cholesterol monitoring industry is a $100 billion including the diagnosing, treating, monitoring and the drug itself, so it would be very difficult change thoughts on this, obviously.
End of selected teleconference notes.
Jeremy Webster, DC
Dr. Jeremy S. Webster received his Bachelors in Electrical Engineering from Oklahoma State University and then attended Parker College in Dallas, TX where he received his Doctorate of Chiropractic. Dr. Webster has post-doctoral training in Neurology from the prestigious Carrick Institute for Graduate Studies. He has specialized training in vestibular rehabilitation which deals with those with vertigo and dizziness. He is currently seeking a diplomate degree in Chiropractic Neurology. Dr. Webster has lectured on the interactions of nutrition and the nervous system to health professionals as well as the public.
Dr. Webster has geared his studies towards the treatment of physiologically and nutritionally based problems that adversely affect health and ultimately prevent weight loss. Nutritional deficiencies, toxicities, and poor neurological function are all assessed in his office in Dallas, Texas.
[www.ravnskov.nu]
[www.thincs.org]
7-dehydrocholesterol reductase
[ghr.nlm.nih.gov]
[www.sciencedaily.com]
[www.sciencedaily.com]
Some Statins Have Unintended Effects and Warrant Closer Monitoring, Study Finds May 2010
(these are rough notes; sorry if there are typos )
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