Carey - I agree. That’s undoubtedly most likely. There have been some studies linking various genetic mutations or flaws to underlying causes that can promote the development of Afib. One is the missense mutation in the voltage-gated potassium channel that relates to autosomal dominant hypomagnesia and that certainly makes sense. There are probably many more, but since that approach apparentby Jackie - AFIBBERS FORUM
Libby - There is an archived section titled Conference Room Sessions and one is titled, The List, which is a collection of success stories of afibbers who managed to control their arrhythmia by various methods that did not involved ablation. It's dated, so we don't know how long their successes lasted, but it does give readers an idea of the variety of contributing factors that can caby Jackie - AFIBBERS FORUM
This gene mutation finding/association was also reported in the discussion at the time about cardiac fibrosis formation as causative for arrhythmia... plus the magnesium deficiency factor is obviously also a contributor. Jackie A missense mutation in the Kv1.1 voltage-gated potassium channel–encoding gene KCNA1 is linked to human autosomal dominant hypomagnesemia J. Clin. Invest. 119(4)by Jackie - AFIBBERS FORUM
Background: In the recent thread that focused on the relevance of Exatest results and in response to the comment by Liz (quote): ......There is probably no one as dedicated to eating the right diet, supplements and making sure the electrolytes were optimal than Jackie, that wasn't enough, as you probably know she has had 3 ablations, uses the exacta test, that is no cure. ....I’d likeby Jackie - AFIBBERS FORUM
George- Your story is 'classic' in the magnesium depletion/fibrosis/AFib department. Long term endurance exercise does cause the fibrosis/necrosis damage that is documented by those such as William Rowe mentioned in the previous posts. Indulge me here while I elaborate on a few of many influences that deplete magnesium. Stress depletes magnesium... endurance exercise is high stby Jackie - AFIBBERS FORUM
Methylation Dysfunction Since several afibbers have tested positive for the polymorphism or gene mutation, MTHFR, which tracks to methylation dysfunction, I thought it would be helpful to post notes from an interview on the topic of Methylation Dysfunction, causes and treatment precautions, especially because many of the signs and symptoms of methylation dysfunction are both common and highlyby Jackie - AFIBBERS FORUM
<; (note the date Author: Jackie (---.clvdoh.adelphia.net) Date: 08-05-06 05:25 Here's a review of a finding about the Connexin 40 Gene Mutations in the Connexin 40 Gene, GJA5, Predisposes Patients to Idiopathic Atrial Fibrillation July 3, 2006 By Sahar Bedrood B.S. and Asher Kimchi M.D. Ottawa, Canada- Atrial Fibrillation is the most common type of cardiac arrhythmia characterby Erling - AFIBBERS FORUM
A few days ago PeggyM got this going with the topic long QT syndrome and genetics and potassium ion channels, o my, having to do with mutations in a gene that codes for the potassium ion channel KCNQ1 that can cause 'long Q-T syndrome' and dangerous dysrhythmia (http://www.afibbers.org/forum/read.php?f=9&i=11342&t=11342). "Channelopathy: A disease involving dysfunction ofby Erling - AFIBBERS FORUM
Reasons for magnesium deficiency have been discussed in many other posts including the Magnesium Absorption post in the Afib Resources section.. I recently was clarifying some of the potential causes of arrhythmia for an afibber and in so doing, read excerpts from The Magnesium Factor (Seeling & Rosanoff) Chapter 7. Here are some of the highlights for the benefit of new readers who may notby Jackie - AFIBBERS FORUM
Joyce - I don't mean to hijack your post but since you bring up the genetic link, this is a perfect opportunity to share some publications on sources of afib incluging the genetic factor. I think in the future, if genetic research ever seriously targets afib, we'll see that there is some form of damage to DNA that creates a gene expression as a result of some environmental influence that eitheby Jackie - AFIBBERS FORUM
Following are my notes from the CCF AF Summit from October '04 on the genetic connection. A special note of interest: The Cleveland Clinic has set up an LAF Gene Bank. Dr. Chung and CCF colleagues are collecting tissue and blood samples so patients and offspring can learn if they have the polymorphisms. Sounds like a large collaborative effort. Her opening comment was that a possibleby Jackie - AFIBBERS FORUM
Hello Dean - I've done a small amount of research in the iron overload area a while back and over the years learned more as it became one of the critical markers that doctors use when testing for 'risk markers' for heart disease in preventive practices. Many naturally occurring substances such as rutin and lactoferrin have been shown to have chelating properties but they all reby Jackie - AFIBBERS FORUM
Here's a review of a finding about the Connexin 40 Gene Mutations in the Connexin 40 Gene, GJA5, Predisposes Patients to Idiopathic Atrial Fibrillation July 3, 2006 By Sahar Bedrood B.S. and Asher Kimchi M.D. Ottawa, Canada- Atrial Fibrillation is the most common type of cardiac arrhythmia characterized by erratic electrical activation of the atrial myocardium, resulting in loss oby Jackie - AFIBBERS FORUM
Cilla, Below is one of the articles detailing the results of the Chinese study on this. This mutation concerned chromosome 11. This is followed by another describing a mutation on chromosome 10. And finally is an abrstract of an article by David Van Wagoner of the Cleveland Clinic that addresses how this fits in with AF in general. Study of four generations of a Chinese family with autosomalby PC - AFIBBERS FORUM
Scott I myself personally would not want to go there and would prefer to find alternative ways to get rid of the depression. I think I have had problems with long QT. Reading the QT is very complicated and other factors have to be taken into consideration. When the QT is read it is not just measured it has to be adjusted. The reason is that the QT interval is also affected by the heart rate. Sby Fran - AFIBBERS FORUM