I was searching for info on nattokinase and found Jackie's old post.
[
www.afibbers.org]
Jackie mentions PAI-1
(Remember that the risk of stroke or MI is higher during the early morning hours before awakening because levels of PAI-1 are low and clotting is easier then. (Plasmin Activator Inhibitor-1). So it's smart to always take a bedtime dose.
Then there's this: [
medicalxpress.com]
Scientists also have found a correlation between PAI-1 levels in blood and the development of disease due to plaque formation and blockages in blood vessels.
More on this. [
youtu.be]
Nattokinase and clotting factors VII, VIII, Von Willebrand
[
pubmed.ncbi.nlm.nih.gov]
Bottom line, preventing clots is critical for not having a heart attack, stroke or dying. (lots of cautions and don't want to over do it but clot prevention is the fire at the AFIB and CVD front door.