Flecanide/ heart failure / QRS June 19, 2022 08:19AM |
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Re: Flecanide/ heart failure / QRS June 19, 2022 10:16AM |
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Re: Flecanide/ heart failure / QRS June 19, 2022 11:17AM |
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Daisy
What is your dose do Flecainide and do you know if you might be a poor metabolizer of CYP2D6, the pathway that Flecainide primarily uses? I ask because if you are a poor metabolizer of that pathway, your dose of Flecainide needs to be lower than ‘normal’ as it can build up in your bloodstream. I learned this the hard way when I started getting ‘wide QRS’ on my Kardia and then it progressed to heart block. This happened after a dose increase of Flecainide. Sorry, I don’t know how high the QRS was as Kardia doesn’t tell you. When I asked my new cardiologist whether he had seen this with Flecainide he said yes and that was a typical pattern—wide QRS leading to heart block. But, I AM a poor metabolizer of CYP2D6 so it is likely that this led to an ‘overdose’ though I was within the normal prescribing range.
Re: Flecanide/ heart failure / QRS June 19, 2022 11:51AM |
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Re: Flecanide/ heart failure / QRS June 19, 2022 12:14PM |
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bettylou4488
im only on 50 am and pm. I don't know if I am a poor metabolizer of CYP2D6. I am familiar with what you are talking about because of head meds for our son but how do you KNOW if you are? what testing? I guess we shall see what the ECG says... what is "heart block" exactly and is it reversible? I really should know the answer to that but I don't.
thanks
Re: Flecanide/ heart failure / QRS June 19, 2022 12:16PM |
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Re: Flecanide/ heart failure / QRS June 19, 2022 01:12PM |
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bettylou4488
im only on 50 am and pm. I don't know if I am a poor metabolizer of CYP2D6. I am familiar with what you are talking about because of head meds for our son but how do you KNOW if you are? what testing?
Re: Flecanide/ heart failure / QRS June 19, 2022 02:14PM |
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bettylou4488
But that has a beta blocker in it yes? not sure how I would tolerate it..
Re: Flecanide/ heart failure / QRS June 19, 2022 03:17PM |
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Carey
But that has a beta blocker in it yes? not sure how I would tolerate it..
No, it does not. It will lower your heart rate some, as most antiarrhythmics do, but that's not because of any beta blockers. Multaq contains nothing but dronedarone, which is in the same class of antiarrhythmics as dofetilide and amiodarone. But t's "milder" than those with fewer side effects. It's the next logical choice (and there aren't many more).
Re: Flecanide/ heart failure / QRS June 19, 2022 03:18PM |
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Re: Flecanide/ heart failure / QRS June 19, 2022 10:28PM |
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Carey
But that has a beta blocker in it yes? not sure how I would tolerate it..
No, it does not. It will lower your heart rate some, as most antiarrhythmics do, but that's not because of any beta blockers. Multaq contains nothing but dronedarone, which is in the same class of antiarrhythmics as dofetilide and amiodarone. But it's "milder" than those and has fewer side effects. It's the next logical choice (and there aren't many more).
Re: Flecanide/ heart failure / QRS June 20, 2022 12:46AM |
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Re: Flecanide/ heart failure / QRS June 20, 2022 11:08AM |
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Re: Flecanide/ heart failure / QRS June 20, 2022 02:43PM |
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bettylou4488
that is what is written on the EKG. I don't know if they hand calculate like they do with the QT. But in sinus.. so that's super.
Re: Flecanide/ heart failure / QRS June 20, 2022 09:52PM |
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Carey
that is what is written on the EKG. I don't know if they hand calculate like they do with the QT. But in sinus.. so that's super.
I don't know why anyone would hand calculate either number when the EKG machine does it for you with perfect accuracy. The numbers you see on the EKG are the numbers you have.
Re: Flecanide/ heart failure / QRS June 21, 2022 12:17AM |
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Re: Flecanide/ heart failure / QRS June 21, 2022 08:21PM |
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bettylou4488
Also- I have a complicated history (congential/ 5 open heart surgeries).. Several years ago when I went on metropolol my BNP (blood test measurement-ish for heart failure) was very high and so they said I had "heart failure" .. never mind that when I went off the metropolol, it went back down. My latest BNP was 70 with is very very normal. My ejection fraction is normal. BUT I feel now on the flec like I did on the metropolol. I take extra lasix right now from time to time.
Re: Flecanide/ heart failure / QRS June 22, 2022 07:44PM |
Registered: 6 years ago Posts: 523 |
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Carey
The EKG saying "abnormal" is a bunch of noise you can safely ignore. Nobody -- and I mean nobody -- pays attention to the diagnostics EKG machines spew out. But their measurement of things like QRS duration and QTc are 100% accurate. A human cannot possibly be more accurate, so all I can imagine is that your docs are applying some sort of unique formula to you due to your other conditions.