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What is the nature of ablated tissue?

Posted by PavanPharter 
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PavanPharter
What is the nature of ablated tissue?
June 17, 2022 10:44AM
Does anyone know what is the nature of ablated tissue? Is it a scar like burnt material, or is it fibrotic? Is there anything that can undo an ablation?

Is the nature different from standard ablation vs PFA?
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Carey
Re: What is the nature of ablated tissue?
June 17, 2022 08:50PM
It turns into scar tissue, just as any tissue burned severely enough would. The purpose of the procedure is that scar tissue doesn't conduct electrical signals like healthy heart tissue does, so it creates a fence around the source of the afib signals.

PFA ablations do the same thing, just more safely.
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SailorGuy1
Re: What is the nature of ablated tissue?
June 25, 2022 12:59PM
PFA does not cause scar or char; it’s a non thermal modality. An electric field is passed over the desired tissues and tiny doors (nano pores) are created causing cell contents to exit through the cellular membrane. Normal homeostasis ceases and the cells/tissues become non-conductive. The extra cellular matrix remains in tact.
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frankangelo
Re: What is the nature of ablated tissue?
June 25, 2022 03:47PM
Quote
SailorGuy1
PFA does not cause scar or char; it’s a non thermal modality. An electric field is passed over the desired tissues and tiny doors (nano pores) are created causing cell contents to exit through the cellular membrane. Normal homeostasis ceases and the cells/tissues become non-conductive. The extra cellular matrix remains in tact.

Amazing! Do you know why it is limited only to PVI?
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SailorGuy1
Re: What is the nature of ablated tissue?
June 25, 2022 04:30PM
Not sure, maybe the current catheter design’s limit PFA to PVI plus posterior wall. There currently are trials underway focused around focal catheter’s, Acutis Medical and Farapulse to name two companies. Farapulse was recently purchased by Boston Scientific. I bet Dr Natale would be able shine light on this, he is very knowledgeable on PFA.
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Carey
Re: What is the nature of ablated tissue?
June 25, 2022 05:22PM
Quote
SailorGuy1
PFA does not cause scar or char; it’s a non thermal modality.

Yes, you're right. I shouldn't have said scar but rather a lesion. In any case, the end result is the same: non-conductive tissue.
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