Published in Cardiology
Journal Scan / Research · March 29, 2020
Clinical and Pharmacological Effects of Apixaban Dose Adjustment
JACC: Journal of the American College of Cardiology
TAKE-HOME MESSAGE
Patients with atrial fibrillation and two or more dose-adjustment criteria treated with apixaban 2.5 mg twice daily were assessed to evaluate the effects of dose adjustment on clinical and pharmacological outcomes. Although the apixaban exposure was lower in dose-adjusted patients compared with those receiving the standard dose, reductions in D-dimers and PF1+2 were comparable in the two populations. Similarly, the efficacy of the lower dose for preventing stroke or systemic embolism and death was similar to that of the standard dose.
The lower dose of apixaban for patients with two or more dose-adjustment criteria appears to be safe and effective.
Edited 1 time(s). Last edit at 03/29/2020 08:07AM by JoyWin.