Hi Gill - I believe Shannon posted something to the effect that overall performance/efficacy was found to be better with Eliquis.
As George mentions, since there is no antidote yet, it seems logical and better to have a 'lesser' dose taken twice a day rather than one larger dose that lasts 24 hours.
I've been on Eliquis for a couple years and fortunately had the dose reduced to the half dose or 2.5 mg twice a day.
Unfortunately, for me, it is not without side effects.
Jackie