Magnesium ions show promise in slowing progression of Alzheimer's disease in mice

Is this the same type of Magnesium we take for Afib?

New research published in the December 2015 issue of The FASEB Journal, shows that in mouse models of the disease oral administration of magnesium-L-threonate (MgT) alleviated cognitive decline by suppressing the Aβ deposition in amyloid plaques in an APH-1α/1β-dependent manner. Although questions still remain about how MgT permeates the blood-brain barrier, the work suggests that scientists may have found the key to a new series of Alzheimer's disease treatments.

http://medicalxpress.com/news/

Jake,

No reason MagT wouldn't work with afib, too. However, not typically what we take. It is more expensive (especially for me and the quantity of mag i take. Would be worth it of it helps brain function.

Thanks for the post.

George

While researching this site I found that: "Alzheimer Disease tends to progress faster in patients with AF than in those free of afib. This observation is not really surprising since AD and AF share the same risk factors".

And this one: " a study concludes that AF is associated with an approximately 1% per year absolute increase in the risk of developing dementia, mostly Alzheimer’s disease".

So, if the magnesium we use for AFIB could help address both health problems that would be a win-win.

Along with my other magnesium, I use Designs for Health NeuroMag ... following is their tech data info... and this link is a report by functional neurologist, David Perlmutter on the threonate form of magnesium: [www.drperlmutter.com]. Retired neurosurgeon, Russell Blaylock has also written on the benefits of the threonate form. If I can locate those clips, I'll include later on.

Jackie

NeuroMag - Keeping the brain and neurons healthy

NeuroMag™ features the unique, patented, chelated mineral Magtein™, which is magnesium chelated to threonic acid (magnesium L-threonate). This ionophore has been found to be supe¬rior to other forms of magnesium at getting through the blood brain barrier as it is able to transport ions (in this case magnesium ions) across lipid membranes, including brain cells.

Why magnesium for the brain?
Magnesium deficiency is well known to produce neuropathologies. Only 16% of the magnesium found in whole wheat remains in refined flour, and magnesium has been removed from most drinking water supplies, setting a stage for magnesium deficiency. This is aggravated by the fact that magnesium is depleted by stress, sweating, alcohol consumption and many medications. Magnesium ions regulate calcium ion flow in neuronal calcium channels, helping to regulate neuronal nitric oxide production. In magnesium deficiency, neuronal requirements for magnesium may not be met, causing neuronal damage, which could manifest as memory loss, depres¬sion and more.

Anxiety disorders, such as phobias and post traumatic stress disorder, are among the most com¬mon mental disorders and are associated with magnesium deficiency. Stress exposure, depending on its intensity and duration, affects cognition and learning. Follows is a direct quote from a study published in the Journal of Neurosciences, 2011: “Studies suggest that enhancement of plasticity in certain brain regions such as the prefrontal cortex (PFC) and/or hippocampus might enhance the efficacy of cognitive therapy. We found that elevation of brain magnesium, by a novel magnesium compound [magnesium-l-threonate (MgT)], enhances synaptic plasticity in the hippocampus and learning and memory in rats. Here, we show that MgT treatment enhances retention of the extinction of fear memory, without enhancing, impairing, or erasing the original fear memory.” Even aged rats showed improvement in memory.

Several studies indicate that these same synaptic connections in the brain hippocampus, a critical brain region for learning and memory, decline during aging. Studies have also found low levels of magnesium in the brains of patients suffering from Alzheimer’s disease. NeuroMag’s Magtein™ was found in animal studies to increase learning ability, working memory, and short- and long-term memory. NeuroMag™ enhances functioning of the hippocampus by improving synaptic plasticity and NMDA (N-Methyl-D-aspartate) receptor-dependent signal¬ing. Researchers at MIT conclude that elevating brain magnesium levels with Magtein™ may be beneficial in enhancing cognitive abilities and preventing age-related memory decline. Increasing plasticity in the prefrontal cortex and amygdala of the brain improves memory because these brain areas are also deeply involved in mediating the effects of exposure to stress on memory.

Recommended Use
• 2 grams for maintenance
• 3-4 grams for those with memory loss or recognition difficulties

For best results, take NeuroMag™ in divided doses.

Suggested Companion Products:
NeuroMag™ may work well with EMF Protect™ or Brain Vitale™


References:
1. Effects of elevation of brain magnesium on fear conditioning, fear extinction, and synaptic
plasticity in the infralimbic prefrontal cortex and lateral amygdala. Abumaria N, et al. J
Neurosci. 2011 Oct 19;31(42):14871-1.
2. Kalzium ist nicht alles. Bush AI. Neuron. 2010 Jan 28;65(2):143-4.
3. Enhancement of learning and memory by elevating brain magnesium. Slutsky I, et al. Neuron.
2010 Jan 28;65(2):165-77.
4. The role of the medial prefrontal cortex-amygdala circuit in stress effects on the extinction of
fear. Akirav I, Maroun M. Neural Plast. 2007; 2007:30873. Epub 2007 Jan 1

NeuroMag™ may support:
• Recall
• Relaxation
• Sleep
• Cognition
• Age-related memory decline (Alzheimer’s)
• Post traumatic stress disorder
• Anxiety
• Phobias
• ADHD
• Depression
• Anti-aging

On the magnesium topic and neurological protection ... this study abstract:


Magnesium deficiency and stress: Issues of their relationship, diagnostic tests, and approaches to therapy
Ter Arkh. 2015;87(9):114-22.
Tarasov EA, et al.

Abstract
(AA) Magnesium plays an important role in the functions of the central nervous system. It takes part in the regulation of the cell membrane, the transmembrane transport of calcium and sodium ions, and metabolic reactions that produce, accumulate, transfer, and utilize energy, free radicals, and their oxidation products.

The magnesium-containing substances include many sequestered antigens, such as glial fibrillary acidic protein, S100, and neuron-specific enolase; magnesium may act as a neuroprotector that is able to modulate the regulation of blood-brain barrier permeability.

Investigations have demonstrated a relationship between the manifestations of stress reactions (anxiety, autonomic dysfunction, and maladjustment) and magnesium deficiency (MD). Thus, mental and physical stresses cause an increase in magnesium elimination from the body. MD in turn enhances a response to stress, by paradoxically aggravating its sequels. Compensation for MD increases the ability of the nervous system to resist stress.

The valid diagnosis of MD present difficulties; namely, a blood magnesium concentration decrease below 0.8 mmol/l is evidence of MD; but the constant blood level of magnesium may be long maintained due to its release from the bone tissue depot. So it is necessary to keep in mind the clinical manifestations of MD.

The authors have developed and tested a simple rapid MD assessment test and a stress resistance self-rating test. The proposed tests will help to screen stress resistance and MD in outpatient settings.

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