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Histamines and Arrhythmia
Posted by Jackie
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Histamines and Arrhythmia June 11, 2015 08:34AM |
Registered: 6 years ago Posts: 18,881 |
Histamines and arrhythmia
Most often, when we talk about histamine release, we commonly think about responses to allergens. A typical description of histamine’s function would read something like this:
On a general level, histamine is a chemical neurotransmitter produced by the body during an allergic reaction, most noticeably causing skin, nose, throat, mucosa and lung irritation (itchiness, redness, swelling, rash, cough and phlegm) or in response to various allergens including insect bites or topical irritants, dust pollen, food allergies. These reactions are part of the inflammatory response, which is an important part of the overall immune response. Other functions: histamine helps regulate physiological function in the gut, helps to regulate sleep, and aids the sexual response. [1]
In the latest issue of Townsend Letter (June 2015), a clip from Julia Klotter’s “Shorts” column indicates that “Histamine intolerance is based on an imbalance between the buildup and breakdown of histamine. Histamine stimulates pain-sensitive nerve fibers, vasodilation, gastric acid secretion, smooth muscle contraction, mucus secretion, endothelial permeability and tachycardia/arrhythmia and the typical reactions to allergens such as sneezing, wheezing, hives and itching. Too much histamine can also produce dizziness, nausea hypotension, abdominal cramps, diarrhea, meteorism, cyclical headaches and dysmenorrhea in women. High histamine levels have been associated with Crohn’s disease, ulcerative colitis, allergic enteropathy, food allergies, colorectal polyps and carcinomas. [2]
Most interesting: The excessive histamine results from consumption of too many histamine-rich foods and/or insufficient amounts of the enzyme diamine oxidase (DAO) and when DAO is not available in sufficient supply, then headache, rhinitis, flushing, diarrhea, tachycardias or arrhythmias and other symptoms of histamine intolerance arise. The authors of the quoted study for this article caution that “All medications, in particular long-term treatments, should be taken into account when interpreting histamine intolerance and DAO levels.”
Now, even more interesting and telling… support for what is commonly mentioned about magnesium being needed for over 350 enzymatic reactions in the body… and, in this case, magnesium is needed to produce the enzyme (DAO) that manages excessive amount of histamine. So connecting the dots: a magnesium deficiency … in the presence of histamine overload…. is attributed to tachycardia and arrhythmias after consuming a high histamine food content meal… in some individuals… as noted in the referenced report: Histamine intolerance in clinical practice 2006 [3]
A histamine-reduced diet is the primary treatment. Histamine-rich foods include aged/matured foods such as wine, aged cheese, cured meats, yeast and sauerkraut. Even some low histamine-rich foods can promote the release of stored histamine and produce symptoms… including: citrus fruit, strawberries, pineapple, tomato, spinach, chocolate, egg white and shell fish.
It’s suggested that people with low DAO activity may benefit from supplementing with vitamins B6 and C as DAO activity depends on these and copper as cofactors. Vitamin C is known to help with histamine’s breakdown. [3]
Once again, when examining closely the dietary habits of afibbers, especially those just beginning with Afib symptoms, we should look carefully at food intake relating to histamine release. We have often talked about methylation defect problems so take note of the following clips from Dr. Eric Braverman’s book, The Edge Effect. Just one more reason to continue emphasis on the fundamental basics involved in recognizing and addressing the important role of magnesium deficiency’s role in arrhythmia.
Also following is a recommendation for foods that help increase the DAO enzyme.
Jackie
Related clips:
From the Referenced Study
Patients frequently complain of headache, rhinitis, flushing, diarrhea, tachycardias or
arrhythmias following ingestion of specific foods. Because these symptoms are reminiscent
of allergy, allergy testing is usually performed. However, these tests are often negative for an
IgE mediated immune response. In these cases, histamine intolerance should be considered as
a possible diagnosis. Around one percent of the population is affected by this condition (1).
The following is an overview of the etiology, diagnosis and treatment of this often poorly
recognized syndrome. Its recognition is important both because of the wide range of
specialties to whom it may present, with its broadly ranging symptomatology, and because
it is relatively easily treatable, with good effect on symptoms and therefore quality of life.
Dtsch Arztebl 2006; 103(51–52): A 3477–83
Eric Braverman, MD, well-known expert on amino acids, indicates in his book, The Edge Effect, that …”excessive histamine results because of the inadequate methylation in liver detoxification and that individuals with high-histamine levels may be due to a metabolic imbalance that results from under-methylation. As a consequence, these individuals overproduce and retain excessive levels of histamine. Histamine is a substance in the body that has wide ranging effects. There are receptors for histamine in the brain, stomach, skin, lungs, mucus membranes, blood vessels, etc. For some individuals, high levels of blood histamine (called histadelia) have psychological, behavioral, and cognitive symptoms.
The Edge Effect by Eric R. Braverman, MD.
Many patients with obsessive-compulsive tendencies, “oppositional-defiant disorder,” or seasonal depression are under-methylated, which is associated with low serotonin levels. Often with inhalant allergies, frequent headaches, perfectionism, competitiveness and other distinctive symptoms and traits. Tend to be very low in calcium, magnesium, methionine, and vitamin B-6 with excessive levels of folic acid. People with histadelics have a positive effect from SSRIs and other serotonin-enhancing medications (Paxil, Zoloft, Prozac, Celexa, Effexor, etc.) because methylation is a step in the manufacture of mood stabilizing neurotransmitters. Unfortunately, histadelics often have nasty side effects with these medications.
Histamine excess can be manifest as asthma, vasomotor rhinitis, allergic skin disorders with pruritis, excess stomach acid production (acts as a gastric hormone to stimulate flow of HCl), saliva, tears, and thin nasal and bronchial secretions, and certain types of vascular headaches. This is the basis of anti-histamine medications. Excessive histamine results because of the inadequate methylation in liver detoxification. Histamine opposes adrenalin in its effects and as expected fatigue occurs just as it occurs in adrenal exhaustion.
Biochemical treatment revolves around antifolates, especially calcium and methionine. Certain forms of buffered vitamin C can help by providing calcium and ascorbic acid. Three to six months of nutrient therapy are usually needed to correct this chemical imbalance. As in most biochemical therapies, the symptoms usually return if treatment is stopped.
Methylation is involved in DNA synthesis, masking and unmasking of DNA, detoxification, heavy mental detoxification, nerve myelination, carnitine and coenzyme Q 10 synthesis. The relationship of mood and behavior to Histadelia is due to the fact that methylation is involved in neurotransmitter synthesis.” [aaronjreid.wordpress.com]
How can I increase the enzyme "diamine oxidase" in my body?
Dr. Arun Phophalia replied 3 years ago.
Hello, Following natural supplements would increase the diamine oxidase in the body;
1) Mangosteen, which is a fruit extract available at health stores.
2) Butterbur.
The following foods can increase the diamine oxidase in the body;
1) chamomile,
2) saffron,
3) anise,
4) fennel,
5) caraway,
6) licorice,
7) cardamom and
8) black seed.
Selective testing for plasma peptides such as gastrin, calcitonin, vasoactive intestinal polypeptide, and somatostatin, as well as urine excretion of 5-hydroxyindole acetic acid, metanephrine, or histamine and other tests of endocrine function, such as measurement of thyroid-stimulating hormone and serum thyroxine levels or an adrenocorticotropin-stimulation test for adrenal insufficiency, can be considered by your physician, for your symptoms of diarrhea and itching. An aspirate of small bowel contents for quantitative culture or breath tests with glucose or isotopically labeled xylose can be used to establish the presence of small bowel bacterial overgrowth. Read more: [www.justanswer.com]
References
[1] [www.sepa.duq.edu]
[2] Townsend Letter, June 2015 [www.townsendletter.com]
[3] Histamine Intolerance in Clinical Practice REVIEW ARTICLE
Maintz L, Bieber, T, Novak, N. Histamine intolerance in clinical practice.[translation] DtschArtztebl, 2006:103(51-52);A3477-A3483. Available at: [www.aerzteblatt.de]
SUMMARY
Histamine intolerance results from disequilibrium of accumulated histamine and
the capacity for histamine degradation. The main enzyme for metabolism of ingested histamine
is diamine oxidase (DAO). It has been proposed that DAO as a secretory protein might be
responsible for scavenging extracellular histamine after mediator release. Inadequate histamine
degradation based on a reduced DAO activity and the consecutive excess of histamine may
cause numerous symptoms in multiple organs such as diarrhoea, headache, hypotension, arrhythmias,
urticaria, pruritus, flushing and even asthma after ingestion of histamine-rich food, alcohol or drugs
releasing histamine or blocking DAO.
The multifaceted presentation means that the condition is frequently missed. Discussion:
In patients with the above clinical picture, with negative allergological investigations and no
general medical disease, histamine intolerance should be considered. After diagnosis, patients
affected by Histamine intolerance improve considerably by relatively simple therapeutic measures
consisting of a histamine-free diet – if necessary – supported by antihistamines or substitution
of DAO. Dtsch Arztebl 2006; 103(51–52): A 3477–8
Magnesium Part 3: The wrath of histamine
In the first 2 parts of this blog series we went over the importance of magnesium to the metabolic syndrome and lifestyle factors that contribute to magnesium wasting. If you haven't read those two blogs they can be found here and here. If you remember from part 1, one of the important functions of magnesium is to help create the histamine metabolizing enzyme Diamine Oxidase (DAO). In magnesium deficient rats, DAO activity is decreased to 50% after 8 days of magnesium deficiency and it returns to baseline once magnesium is reintroduced back in to the diet(1). In addition, histidine decarboxylase (HDC) activity is increased in some of the tissues of the magnesium deficient rats, particularly the spleen and peritoneum but not the skin(2). HDC is an enzyme that makes histamine from histidine, an amino acid. It is this conversion as well as certain foods that contain and/or liberate histamine that can be potentially problematic for someone with an existing magnesium deficiency.
Histamine intolerance is a condition where histamine accumulates in the body as a result of defective histamine metabolism(3). This occurs as a result of reduced DAO activity, something that is made worse by a magnesium deficiency as referenced in the above study. In addition, HDC activity increases which increases the conversion of histidine to histamine in the gut and circulation. Histidine can be found in most high protein foods and is an essential amino acid. As histamine accumulates in the body, numerous symptoms related to allergic reactions can occur including rash, GI symptoms, headache, hypotension, heart arrhythmia, and a host of other symptoms. Below is a flow chart of symptoms taken from reference #(3).
Continue: [synergyhw.blogspot.com]
Most often, when we talk about histamine release, we commonly think about responses to allergens. A typical description of histamine’s function would read something like this:
On a general level, histamine is a chemical neurotransmitter produced by the body during an allergic reaction, most noticeably causing skin, nose, throat, mucosa and lung irritation (itchiness, redness, swelling, rash, cough and phlegm) or in response to various allergens including insect bites or topical irritants, dust pollen, food allergies. These reactions are part of the inflammatory response, which is an important part of the overall immune response. Other functions: histamine helps regulate physiological function in the gut, helps to regulate sleep, and aids the sexual response. [1]
In the latest issue of Townsend Letter (June 2015), a clip from Julia Klotter’s “Shorts” column indicates that “Histamine intolerance is based on an imbalance between the buildup and breakdown of histamine. Histamine stimulates pain-sensitive nerve fibers, vasodilation, gastric acid secretion, smooth muscle contraction, mucus secretion, endothelial permeability and tachycardia/arrhythmia and the typical reactions to allergens such as sneezing, wheezing, hives and itching. Too much histamine can also produce dizziness, nausea hypotension, abdominal cramps, diarrhea, meteorism, cyclical headaches and dysmenorrhea in women. High histamine levels have been associated with Crohn’s disease, ulcerative colitis, allergic enteropathy, food allergies, colorectal polyps and carcinomas. [2]
Most interesting: The excessive histamine results from consumption of too many histamine-rich foods and/or insufficient amounts of the enzyme diamine oxidase (DAO) and when DAO is not available in sufficient supply, then headache, rhinitis, flushing, diarrhea, tachycardias or arrhythmias and other symptoms of histamine intolerance arise. The authors of the quoted study for this article caution that “All medications, in particular long-term treatments, should be taken into account when interpreting histamine intolerance and DAO levels.”
Now, even more interesting and telling… support for what is commonly mentioned about magnesium being needed for over 350 enzymatic reactions in the body… and, in this case, magnesium is needed to produce the enzyme (DAO) that manages excessive amount of histamine. So connecting the dots: a magnesium deficiency … in the presence of histamine overload…. is attributed to tachycardia and arrhythmias after consuming a high histamine food content meal… in some individuals… as noted in the referenced report: Histamine intolerance in clinical practice 2006 [3]
A histamine-reduced diet is the primary treatment. Histamine-rich foods include aged/matured foods such as wine, aged cheese, cured meats, yeast and sauerkraut. Even some low histamine-rich foods can promote the release of stored histamine and produce symptoms… including: citrus fruit, strawberries, pineapple, tomato, spinach, chocolate, egg white and shell fish.
It’s suggested that people with low DAO activity may benefit from supplementing with vitamins B6 and C as DAO activity depends on these and copper as cofactors. Vitamin C is known to help with histamine’s breakdown. [3]
Once again, when examining closely the dietary habits of afibbers, especially those just beginning with Afib symptoms, we should look carefully at food intake relating to histamine release. We have often talked about methylation defect problems so take note of the following clips from Dr. Eric Braverman’s book, The Edge Effect. Just one more reason to continue emphasis on the fundamental basics involved in recognizing and addressing the important role of magnesium deficiency’s role in arrhythmia.
Also following is a recommendation for foods that help increase the DAO enzyme.
Jackie
Related clips:
From the Referenced Study
Patients frequently complain of headache, rhinitis, flushing, diarrhea, tachycardias or
arrhythmias following ingestion of specific foods. Because these symptoms are reminiscent
of allergy, allergy testing is usually performed. However, these tests are often negative for an
IgE mediated immune response. In these cases, histamine intolerance should be considered as
a possible diagnosis. Around one percent of the population is affected by this condition (1).
The following is an overview of the etiology, diagnosis and treatment of this often poorly
recognized syndrome. Its recognition is important both because of the wide range of
specialties to whom it may present, with its broadly ranging symptomatology, and because
it is relatively easily treatable, with good effect on symptoms and therefore quality of life.
Dtsch Arztebl 2006; 103(51–52): A 3477–83
Eric Braverman, MD, well-known expert on amino acids, indicates in his book, The Edge Effect, that …”excessive histamine results because of the inadequate methylation in liver detoxification and that individuals with high-histamine levels may be due to a metabolic imbalance that results from under-methylation. As a consequence, these individuals overproduce and retain excessive levels of histamine. Histamine is a substance in the body that has wide ranging effects. There are receptors for histamine in the brain, stomach, skin, lungs, mucus membranes, blood vessels, etc. For some individuals, high levels of blood histamine (called histadelia) have psychological, behavioral, and cognitive symptoms.
The Edge Effect by Eric R. Braverman, MD.
Many patients with obsessive-compulsive tendencies, “oppositional-defiant disorder,” or seasonal depression are under-methylated, which is associated with low serotonin levels. Often with inhalant allergies, frequent headaches, perfectionism, competitiveness and other distinctive symptoms and traits. Tend to be very low in calcium, magnesium, methionine, and vitamin B-6 with excessive levels of folic acid. People with histadelics have a positive effect from SSRIs and other serotonin-enhancing medications (Paxil, Zoloft, Prozac, Celexa, Effexor, etc.) because methylation is a step in the manufacture of mood stabilizing neurotransmitters. Unfortunately, histadelics often have nasty side effects with these medications.
Histamine excess can be manifest as asthma, vasomotor rhinitis, allergic skin disorders with pruritis, excess stomach acid production (acts as a gastric hormone to stimulate flow of HCl), saliva, tears, and thin nasal and bronchial secretions, and certain types of vascular headaches. This is the basis of anti-histamine medications. Excessive histamine results because of the inadequate methylation in liver detoxification. Histamine opposes adrenalin in its effects and as expected fatigue occurs just as it occurs in adrenal exhaustion.
Biochemical treatment revolves around antifolates, especially calcium and methionine. Certain forms of buffered vitamin C can help by providing calcium and ascorbic acid. Three to six months of nutrient therapy are usually needed to correct this chemical imbalance. As in most biochemical therapies, the symptoms usually return if treatment is stopped.
Methylation is involved in DNA synthesis, masking and unmasking of DNA, detoxification, heavy mental detoxification, nerve myelination, carnitine and coenzyme Q 10 synthesis. The relationship of mood and behavior to Histadelia is due to the fact that methylation is involved in neurotransmitter synthesis.” [aaronjreid.wordpress.com]
How can I increase the enzyme "diamine oxidase" in my body?
Dr. Arun Phophalia replied 3 years ago.
Hello, Following natural supplements would increase the diamine oxidase in the body;
1) Mangosteen, which is a fruit extract available at health stores.
2) Butterbur.
The following foods can increase the diamine oxidase in the body;
1) chamomile,
2) saffron,
3) anise,
4) fennel,
5) caraway,
6) licorice,
7) cardamom and
8) black seed.
Selective testing for plasma peptides such as gastrin, calcitonin, vasoactive intestinal polypeptide, and somatostatin, as well as urine excretion of 5-hydroxyindole acetic acid, metanephrine, or histamine and other tests of endocrine function, such as measurement of thyroid-stimulating hormone and serum thyroxine levels or an adrenocorticotropin-stimulation test for adrenal insufficiency, can be considered by your physician, for your symptoms of diarrhea and itching. An aspirate of small bowel contents for quantitative culture or breath tests with glucose or isotopically labeled xylose can be used to establish the presence of small bowel bacterial overgrowth. Read more: [www.justanswer.com]
References
[1] [www.sepa.duq.edu]
[2] Townsend Letter, June 2015 [www.townsendletter.com]
[3] Histamine Intolerance in Clinical Practice REVIEW ARTICLE
Maintz L, Bieber, T, Novak, N. Histamine intolerance in clinical practice.[translation] DtschArtztebl, 2006:103(51-52);A3477-A3483. Available at: [www.aerzteblatt.de]
SUMMARY
Histamine intolerance results from disequilibrium of accumulated histamine and
the capacity for histamine degradation. The main enzyme for metabolism of ingested histamine
is diamine oxidase (DAO). It has been proposed that DAO as a secretory protein might be
responsible for scavenging extracellular histamine after mediator release. Inadequate histamine
degradation based on a reduced DAO activity and the consecutive excess of histamine may
cause numerous symptoms in multiple organs such as diarrhoea, headache, hypotension, arrhythmias,
urticaria, pruritus, flushing and even asthma after ingestion of histamine-rich food, alcohol or drugs
releasing histamine or blocking DAO.
The multifaceted presentation means that the condition is frequently missed. Discussion:
In patients with the above clinical picture, with negative allergological investigations and no
general medical disease, histamine intolerance should be considered. After diagnosis, patients
affected by Histamine intolerance improve considerably by relatively simple therapeutic measures
consisting of a histamine-free diet – if necessary – supported by antihistamines or substitution
of DAO. Dtsch Arztebl 2006; 103(51–52): A 3477–8
Magnesium Part 3: The wrath of histamine
In the first 2 parts of this blog series we went over the importance of magnesium to the metabolic syndrome and lifestyle factors that contribute to magnesium wasting. If you haven't read those two blogs they can be found here and here. If you remember from part 1, one of the important functions of magnesium is to help create the histamine metabolizing enzyme Diamine Oxidase (DAO). In magnesium deficient rats, DAO activity is decreased to 50% after 8 days of magnesium deficiency and it returns to baseline once magnesium is reintroduced back in to the diet(1). In addition, histidine decarboxylase (HDC) activity is increased in some of the tissues of the magnesium deficient rats, particularly the spleen and peritoneum but not the skin(2). HDC is an enzyme that makes histamine from histidine, an amino acid. It is this conversion as well as certain foods that contain and/or liberate histamine that can be potentially problematic for someone with an existing magnesium deficiency.
Histamine intolerance is a condition where histamine accumulates in the body as a result of defective histamine metabolism(3). This occurs as a result of reduced DAO activity, something that is made worse by a magnesium deficiency as referenced in the above study. In addition, HDC activity increases which increases the conversion of histidine to histamine in the gut and circulation. Histidine can be found in most high protein foods and is an essential amino acid. As histamine accumulates in the body, numerous symptoms related to allergic reactions can occur including rash, GI symptoms, headache, hypotension, heart arrhythmia, and a host of other symptoms. Below is a flow chart of symptoms taken from reference #(3).
Continue: [synergyhw.blogspot.com]
|
Re: Histamines and Arrhythmia June 16, 2015 01:10PM |
Registered: 9 years ago Posts: 100 |
Jackie,
Interesting, thank you. I read this article:
[ [www.sciencedaily.com] ] "Role for immune cells known as mast cells in atrial fibrillation"
several years ago and it prompted me to buy an couple of good HEPA air filters for my home. I've always been bothered by seasonal allergies, the filters help a lot. Especially in the bedroom, I sleep better and wake up without being stuffed up. Didn't seem to help the progression of afib but I got the filters very late in the game.
Interesting, thank you. I read this article:
[ [www.sciencedaily.com] ] "Role for immune cells known as mast cells in atrial fibrillation"
several years ago and it prompted me to buy an couple of good HEPA air filters for my home. I've always been bothered by seasonal allergies, the filters help a lot. Especially in the bedroom, I sleep better and wake up without being stuffed up. Didn't seem to help the progression of afib but I got the filters very late in the game.
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