Interactions of DHA and Eliquis

I'm trying to find out whether it's okay to take DHA, not fish oil, with Eliquis. I went to Drugs.com and it didn't list DHA, only EPA. There was an interaction of moderate with EPA and Eliquis.

Then I went to [hellopharmacist.com] and it said that there was no problem for humans with DHA and Elliquis, but still rated the interaction as moderate, which doesn't make sense to me.
Interaction Rating
Moderate
Likelihood of Occurrence
Unlikely

Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

I was told that Dr Natale had said taking fish oil is okay, along with a 1/2 dose of Eliquis, but I am taking DHA, not EPA, so it okay since I am taking a full dose of 5mg x 2 of Eliquis?

You're over-analyzing this. Natale's advice would apply to both. The omega-3 supplements in normal doses just don't have enough of a bleeding enhancement risk to matter much. That's why drugs.com and the other site you checked give it a "moderate" rating. They're just trying to tell you to check with your doc because there are people out there who will take outrageous doses of supplements.

Thanks for your reply Carey. But I made a mistake about what Dr Natale said. Evidently, I got that mixed up with some other supplement. He never commented on fish oil to my friend taking 1/2 dose of Elliquis.
Do you still think it is safe to take the DHA? I have been taking 1000mg per day.

Thanks for your help.

I was taking fish oil when I was under his care. Neither he nor two other EPs cared one bit that I was taking it with Eliquis.

Yes, it's perfectly fine in normal doses. Drugs.com is a trustworthy source.

Thanks, Carey. That is very reassuring. I definitely didn't want to stop taking it if I didn't have to. I would have asked my cardiologist who prescribed it for me, but he doesn't seem to know much about supplements.

I found this article by Dr Stephen Sinatra, a well known cardiologist, and thought others would be interested in what he has to say.

"How to Safely Take Fish Oil and Blood Thinners"

So back to our original question: Is it safe to mix fish oil and blood thinning drugs?

I believe it is, as long as the dosages of all drugs (including fish oil) are managed properly.

Modest amounts of fish oil, say 1–2 grams daily, generally can be tolerated even if you are taking prescription blood thinners. However, doing this is not without some risk—so it’s absolutely essential that you be up front with your doctor about the fish oil products you’re taking and how much, to avoid unsafe drug interactions. I cannot emphasize this enough. You must work collaboratively with your physician and regularly monitor the clotting agents in your blood. (Prepare for the conversation by reading how to talk to your doctor about supplements.) It’s also crucial that you don’t replace a blood thinning therapy that your doctor has prescribed with fish oil, unless that doctor says it’s okay.

Remember, too – blood thinners aren’t limited to prescription medications. Aspirin is also an antiplatelet therapy. If your doctor has prescribed an aspirin regimen for you, you also must tell him or her about your fish oil use. Other supplements can have blood thinning effects, too. These include garlic, nattokinase, vitamin E, ginger, and bromelain.

If you find that fish oil causes your blood to thin too much, use it as an opportunity to ask about reducing the dosage of your prescription blood thinner. But don’t give up your fish oil, unless you absolutely have to. The benefits are simply too great to forego.

[heartmdinstitute.com]