Have there been any reports suggesting a possible connection between an Eliquis regimen and GERD/reflux?

I've been on Eliquis pre and post ablation so I researched all the possible side effects.
If you look it up on Drugs.com you will find a category for "gastrointestinal". Dyspepsia (which you may be describing) gastritis, gastroenteritis.... are considered "common" 1 to 10 %. I'm sure GERD fall into that category somewhere, especially if you already have it.

Yes it's very possible. You might want to try a high quality probiotic. A pharmacist recommended Florastar. I've been taking it since I've been on Eliquis and I haven't had any issues.

Travis

I've been on Eliquis for 6 months. I have a hiatal hernia and treat my GERD with Nexium. Absolutely no issues in my case since starting on Eliquis. No GERD for a very long time.