Addressing postmenopausal osteoporosis with vitamin D, calcium, and estrogen is guaranteed to make osteoporosis worse, unless one is serious about increasing dietary magnesium and/or supplementation.
All one needs to know to understand the flow sheets is that vitamin D increases calcium and magnesium absorption, but calcium more than magnesium. Parathormone (PTH) responds to low blood calcium or magnesium by mobilizing these cations from bone. Calcitonin (CT) does the opposite when these two ion blood levels are high.
Osteosclerosis is the opposite of osteoporosis.
Combining vitamin K2 with vitamin D (100 µg of K2 for every 5000 IUs of vitamin D) facilitates the transfer of calcium into bone and probably minimizes the “metastatic calcifications.“
In males the same physiology is in effect, but without the estrogen.