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FLUORIDE-MAGNESIUM INTERACTION
A Machoy-Mokrzynska
Institute of Pharmacology and Toxicology, Pomeranian Medical Academy, Szczecin, Poland
Journal of the International Society for Fluoride Research, Vol. 28 No. 4; November, 1995, pp 175-177
It has now been fifteen years since Marier drew attention to the significance of magnesium in biological interaction with fluorides.(1) The toxic effect of fluoride ion plays a key role in acute Mg deficiency. The amount of F- assimilated by living organisms constantly increases, and Mg absorption diminishes as a consequence of progressively advancing industrialization. Marier gives examples of such retention of both elements in plants (e.g. in pine and tomatoes) and in animals, for instance in bone tissue, blood and kidneys, with the last being thought as the most probable place of Mg-F- interaction.(1) Now, further facts have been observed, which throw a new light on the effects of Mg-F- interaction.
The significance and distribution of Mg in living organisms are widely known and described in textbooks.(2) Fluoride ion clearly interferes with the biological activity of magnesium ion.(3) Present-day Mg deficiencies in humans are the result of intensive expulsion of this element (e.g. under the influence of extensive drinking of alcoholic beverages) or reduced Mg content in the diet, caused, for example, by inappropriate agricultural practices or effects of ecotoxins.(4)
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References:
1 Marier J R.
Observations and implications of the (Mg F) interrelations in bio-systems: a review and comments on magnesium intake and fluoride intake in the modern-day world. Proceedings of the Finnish Dental Society 76. 82-92, 93-102, 1980. (Abstracted in Fluoride 14, 142 1981).
2 Durlach J.
Le magnesium en pratique clinique. Editions Medicales Internationales. Paris 1991.
3 Guminska M.
The effect of magnesium on metabolism in living organisms and medical consequences of its deficiency in man. Folia Medica Cracoviensia 26 1-2, 5-28, 1985.
4 Markiewicz J.
Environmental factors decreasing magnesium content in alimentary chain. Folia Medica Cracoviensia 26 1-2, 5-28, 1985.
5 Strochkova L S, Zhavoronkov A A.
Fluroide as an activator of enzymatic systems. Fluoride 16, 181-186 1983.
6 Chlubek D, Machoy Z.
Significance of the effect of fluorine dose on enzymes activity in vivo and in vitro studies. Bromatologia i Chemia Toksykologiczna 22 3-4, 235-242, 1989.
7 Okazaki M.
Mg2+-F- interaction during hydroxyapatite formation. Magnesium 6 (6) 296-301, 1987.
8 Machoy P, Bober J.
Fluorine-constant component of urinary calculi. Environmental Sciences 2 1 11-15, 1993.
9 Cerklewski F L.
Influence of dietary magnesium on fluoride bioavailability in the rat. American Insitute of Nutrition 117 (3) 456-500, 1987.
10 Machoy Z.
Biochemical mechanisms of fluorine compounds action. Folia Medica Cracoviensia 28 1-2, 61-81, 1987.
11 Collys K, Slop D, Coomans D.
Interaction of magnesium and fluoride in the rehardening and acid resistance of surface-softened bovine enamel in vitro. Magnesium Trace Element 9 (1) 47- 53, 1990.
12 Luoma A R, Luoma H, Raisanen J, Hausen H.
Effect of magnesium and fluoride on the fermentative dissolution of enamel by a streptococcal layer as measured by mircrohardness tester and a proton probe microanalysis. Caries Research 17 430-438, 1983.
13 Sorvari R, Koskinen-Kainulainen M, Sorvari T, Luoma H.
Effect of a sports drink mixture with and without addition of fluoride and magnesium on plaque formation, dental caries and general health of rats. Scandinavian Journal of Dental Research 94 483-490, 1986.
FLUORIDE: published by the International Society for Fluoride Research Editorial Office: 81A Landscape Road, Mt Eden, Auckland 4, NZ Subscription Rate: $40. U.S. Funds per year (quarterly publication)
Edited 1 time(s). Last edit at 01/01/2013 12:12PM by Erling.
