"We chose four tablets for the loading test. Sufficiency of whole human body for iodine/iodide was arbitrarily defined as 90% or more of the ingested amount excreted in the 24-hour urine collection, using 50 mg of the iodine/iodide preparation (four tablets). Orthoiodosupplementation with one tablet a day required up to 18 months to achieve sufficiency in some patients, and in others, sufficiency was not achieved even after two years of supplementation with one tablet/day. With 3-4 tablets/day, however, sufficiency was achieved within three months in most cases. These data support the keen observations of clinicians over the past century, regarding the amount of iodine/iodide needed for iodine/iodide supplementation, 12.5-37.5 mg elemental iodine from Lugol solution.
Orthoiodosupplementation increased urinary excretion of lead, cadmium, arsenic, aluminum, and mercury. Urinary bromide and fluoride levels increased markedly and proportionally to the amount of iodine/iodide ingested. At three tablets a day, urinary fluoride and bromide increased up to 20-fold, although the preluding test levels were not elevated.120 Obesity seems to increase the requirement for iodine/iodide, and this may be due to sequestration of iodine by unsaturated fats. So many factors affect the requirement of iodine/iodide that the best way to assess whole body sufficiency for this element is with the loading test."
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