Conclusion In summary, we have identified AF-specific dysregulated gene networks enriched in cardiac metabolism, ion transport, and immune pathways. Notably, we utilized multiple lines of complementary approaches, including LA tissue transcriptomics-based network module findings, network proximity, and drug-gene signature-based enrichment analysis to identify nine candidate drugs that are putative repurposed drugs for AF. Utilizing multiple lines of synergistic evidence, including in silico prediction from the AF disease module findings, in vitro testing from a-iCM models, and large-scale EHR data-based pharmacoepidemiologics analysis, we nominated metformin for functional validation and identified key molecular signals that help explain metformin’s mechanism of action. We believe that the network medicine approaches presented here, when broadly applied, would significantly catalyze effective treatment development for AF and other cardiovascular diseases. [www.cell.com] https://www.afibbers.org/forum/read.php?9,188982,188982#msg-188982 Tue, 22 Sep 2026 16:54:45 +0000 Phorum 5.2.23 https://www.afibbers.org/forum/read.php?9,188982,189112#msg-189112 https://www.afibbers.org/forum/read.php?9,188982,189112#msg-189112 Mike_the_drummer AFIBBERS FORUM Mon, 16 Jan 2023 07:46:35 +0000 https://www.afibbers.org/forum/read.php?9,188982,189024#msg-189024 https://www.afibbers.org/forum/read.php?9,188982,189024#msg-189024
By eating fewer carbs, no matter what the source (and many vegetables, root or otherwise have carbohydrates in them), you reduce the prevalence of insulin, which means what you eat controls both your serum glucose AND any possible insulinic response.

I have adopted the moderate approach, not the keto approach, not even ketogenic. I try to keep my carb intake below 120 gms/diem. That amounts to a whopping 500 calories each day that insulin must deal with. The rest of the calorific intake comes from fat and protein. After a six month regimen, my blood markers were vastly improved, and my GP was vastly impressed. (:P)]]> gloaming AFIBBERS FORUM Sun, 08 Jan 2023 14:22:43 +0000 https://www.afibbers.org/forum/read.php?9,188982,189021#msg-189021 https://www.afibbers.org/forum/read.php?9,188982,189021#msg-189021 californiagal AFIBBERS FORUM Sun, 08 Jan 2023 07:28:18 +0000 https://www.afibbers.org/forum/read.php?9,188982,189009#msg-189009 https://www.afibbers.org/forum/read.php?9,188982,189009#msg-189009 PavanPharter AFIBBERS FORUM Sat, 07 Jan 2023 12:56:23 +0000 https://www.afibbers.org/forum/read.php?9,188982,189001#msg-189001 https://www.afibbers.org/forum/read.php?9,188982,189001#msg-189001
[clinicaltrials.gov]]]> bettylou4488 AFIBBERS FORUM Fri, 06 Jan 2023 17:33:07 +0000 https://www.afibbers.org/forum/read.php?9,188982,188991#msg-188991 https://www.afibbers.org/forum/read.php?9,188982,188991#msg-188991 Joe AFIBBERS FORUM Thu, 05 Jan 2023 22:57:22 +0000 https://www.afibbers.org/forum/read.php?9,188982,188989#msg-188989 https://www.afibbers.org/forum/read.php?9,188982,188989#msg-188989 www.medrxiv.org]]]> PavanPharter AFIBBERS FORUM Thu, 05 Jan 2023 15:35:56 +0000 https://www.afibbers.org/forum/read.php?9,188982,188983#msg-188983 https://www.afibbers.org/forum/read.php?9,188982,188983#msg-188983 Joe AFIBBERS FORUM Thu, 05 Jan 2023 01:16:45 +0000 https://www.afibbers.org/forum/read.php?9,188982,188982#msg-188982 https://www.afibbers.org/forum/read.php?9,188982,188982#msg-188982 Conclusion

In summary, we have identified AF-specific dysregulated gene networks enriched in cardiac metabolism, ion transport, and immune pathways. Notably, we utilized multiple lines of complementary approaches, including LA tissue transcriptomics-based network module findings, network proximity, and drug-gene signature-based enrichment analysis to identify nine candidate drugs that are putative repurposed drugs for AF. Utilizing multiple lines of synergistic evidence, including in silico prediction from the AF disease module findings, in vitro testing from a-iCM models, and large-scale EHR data-based pharmacoepidemiologics analysis, we nominated metformin for functional validation and identified key molecular signals that help explain metformin’s mechanism of action. We believe that the network medicine approaches presented here, when broadly applied, would significantly catalyze effective treatment development for AF and other cardiovascular diseases.

[www.cell.com]]]> PavanPharter AFIBBERS FORUM Thu, 05 Jan 2023 00:34:50 +0000