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Aspirin

Posted by Elizabeth 
Aspirin
July 03, 2018 02:53PM
Aspirin, it still works



[www.msn.com]
Re: Aspirin
July 04, 2018 02:49AM
Quote
Elizabeth
Aspirin, it still works



[www.msn.com]

“Second, clinical trials of aspirin have already been performed in patients with Alzheimer’s disease. The drug had no beneficial effects on outcome measures and was associated with an increased risk of gastrointestinal hemorrhage.”

Doesn't seem to work for preventing strokes, either
Re: Aspirin
July 04, 2018 07:29AM
Raise cholesterol levels to where they should be instead of producing unnatural drug induced low levels, and toss the aspirin out the window.
Re: Aspirin
July 04, 2018 10:59AM
Quote
hwkmn05
Raise cholesterol levels to where they should be instead of producing unnatural drug induced low levels, and toss the aspirin out the window.

Huh? How did cholesterol come into this?

There's never been any question that aspirin works -- as an antiplatelet drug. If you've got an artificial device in contact with blood flow, such as stents, artificial valves, LAA occlusion devices, etc, or if you're prone to DVTs or have certain types of cancer, aspirin is an absolutely essential drug.
Re: Aspirin
July 04, 2018 01:14PM
Quote
jpeters

Aspirin, it still works


“Second, clinical trials of aspirin have already been performed in patients with Alzheimer’s disease. The drug had no beneficial effects on outcome measures and was associated with an increased risk of gastrointestinal hemorrhage.”

Doesn't seem to work for preventing strokes, either

Then why do doctors recommend aspirin after a person has a heart attack? My mother was on Coumadin and had bleeding from her gastrointestinal. The truth is most drugs suck and have side effects, so I guess we pick our poison.

liz
Re: Aspirin
July 04, 2018 01:35PM
Quote
Elizabeth



Then why do doctors recommend aspirin after a person has a heart attack? My mother was on Coumadin and had bleeding from her gastrointestinal. The truth is most drugs suck and have side effects, so I guess we pick our poison.

liz

At least for afib it didn't appear to decrease strokes, according to a presentation I attended at Alta Bates Hospital. That wouldn't stop doctors from recommending it, though.
Re: Aspirin
July 04, 2018 02:35PM
Where are your clinical trials on Alzheimers and aspirin?

July 2 (UPI) -- Daily low doses of aspirin may help reduce the effects of Alzheimer's disease and protect memory, according to a new study.

Researchers at Rush University Medical Center showed that aspirin decreases plaques in the brain that are leading mechanisms in dementia and memory loss. The team published results of their study in the July issue of The Journal of Neuroscience.

l
Re: Aspirin
July 04, 2018 03:08PM
Quote
Elizabeth
Where are your clinical trials on Alzheimers and aspirin?


l

The quote came out of the article you posted. I didn't bother to check the references.
Re: Aspirin
July 04, 2018 06:34PM
Aspirin is not a benign medication and everyone should be aware of the risks involved in its use – especially long term.
While it can provide relief from pain and certainly, if one thinks they may be having a stroke, some advocate for taking aspirin immediately. However, it’s important to be aware of the many studies indicating the risks of aspirin usage.

Here are a few study results from my files on the risks and adverse effects on this topic.


Jackie

Aspirin causes significant gastroduodenal damage even at the low doses used for cardiovascular protection.
Pubmed Data : Curr Med Res Opin. 2009 Nov;25(11):2785-93.
PMID: 19788350
Study Type : Human Study

Aspirin increases mortality in diabetic patients without cardiovascular disease.
Pubmed Data : Pharmacoepidemiol Drug Saf. 2009 Dec;18(12):1143-9.
PMID: 19672841
Study Type : Human Study

Long-term, low-dose aspirin treatment has little effect on the prevention of venous thromboembolism in initially healthy women.
Pubmed Data : Ann Intern Med. 2007 Oct 16;147(8):525-33.
PMID: 17938390
Study Type : Meta Analysis

In healthy individuals using aspirin 80% experience small bowel mucosal injury.
Abstract Title: Incidence of small bowel injury induced by low-dose aspirin: a crossover study using capsule endoscopy in healthy volunteers.
Abstract Source: Digestion. 2009;79(1):44-51. Epub 2009 Feb 26.
PMID: 19246922
Study Type : Human Study


Aspirin adversely effects cerebral blood flow in vivo, which may explain why research has shown it may increase the risk of ischemic stroke.
Pubmed Data : Neurol Res. 1999 Jul;21(5):488-90.
PMID: 10439430
Study Type : Human Study
Additional Links Diseases : Brain Ischemia, Cerebral Ischemia, Stroke
Problem Substances : Aspirin

Aspirin with or without chronic oral anticoagulant treatment does not reduce mortality or reinfarction, reduces stroke, but is associated with significantly more major bleeding.
Abstract Title:
Long-term effect of chronic oral anticoagulation with warfarin after acute myocardial infarction.
Abstract Source:
Am J Med. 2010 Mar;123(3):250-8.
PMID: 20193834
Study Type : Human Study

Aspirin does not prevent cardiovascular events in diabetes mellitus.
Pubmed Data : Expert Opin Pharmacother. 2010 Jun;11(9):1459-66.
PMID: 20429671
Study Type : Meta Analysis

Patients taking aspirin before an acute coronary syndrome (ACS) are at higher risk of recurrent heart attack.
Pubmed Data : J Am Coll Cardiol. 2010 Oct 19;56(17):1376-85.
PMID: 20946994
Study Type : Meta Analysis

Regular use of aspirin, NSAIDs, or acetaminophen increases the risk of hearing loss in men,
and the impact is larger on younger individuals.
Pubmed Data : Am J Med. 2010 Mar;123(3):231-7.
PMID: 20193831
Study Type : Meta Analysis

Aspirin is a risk factor for colonic diverticular bleeding
Korean J Gastroenterol. 2012 Dec 25 ;60(6):349-54.
PMID: 23242017
Study Type : Human Study


Aspirin treatment reduces ischemic strokes while increasing hemorrhagic stroke
Antiplatelet treatment in ischemic stroke treatment.
Curr Top Med Chem. 2009;9(14):1298-316.
PMID: 19849660
Study Type : Human Study

Aspirin use was associated with increased risks of ischemic stroke in women and hemorrhagic stroke overall in the elderly.
Title: Aspirin use and incident stroke in the cardiovascular health study. CHS Collaborative Research Group.
Stroke. 1998 May;29(5):887-94.
PMID: 9596230
Study Type : Human Study

Aspirin use was not found to lower the risk of heart attack or death from cardiovascular causes.
Abstract Title: A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women.
Abstract Source:
N Engl J Med. 2005 Mar 31;352(13):1293-304. Epub 2005 Mar 7.
PMID: 15753114
Study Type : Human StudyI

In a population-based cohort, aspirin use was significantly associated with an increased risk of major gastrointestinal or cerebral bleeding episodes.
Abstract Title: Association of aspirin use with major bleeding in patients with and without diabetes.
Abstract Source: JAMA. 2012 Jun 6 ;307(21):2286-94.
PMID: 22706834.1
Study Type : Human Study

Abstract Title: Clinical features of gastroduodenal ulcer in Japanese patients taking low-dose aspirin.
Abstract Source: Dig Dis Sci. 2009 Nov 20. Epub 2009 Nov 20.
PMID: 19936921
Study Type : Human Study


Short-term administration of low-dose aspirin is associated with small bowel injuries and blood flow.
Abstract Title: Evaluation of small bowel blood flow in healthy subjects receiving low-dose aspirin.
Abstract Source: World J Gastroenterol. 2011 Jan 14 ;17(2):226-30.
PMID: 21245996
Study Type: Human Study


The risks of aspirin therapy may outweigh the benefits for primary prevention of cardiovascular disease.
Abstract Title: Aspirin for primary prevention of cardiovascular disease?
Abstract Source: Evid Based Med. 2010 Feb;15(1):31-3.
PMID: 20176886
Study Type: Human Study

The active ingredient in aspirin is sodium salicyclate which induces degeneration of cochlea spiral ganglion neurons. This may explain why aspirin use has been associated with Reye's syndrome, tinnitus and hearing loss.
Abstract Title: Salicylate-induced degeneration of cochlea spiral ganglion neurons-apoptosis signaling.
Abstract Source: Neuroscience. 2010 Jun 16;168(1):288-99. Epub 2010 Mar 15.
PMID: 20298761
Study Type : In Vitro Study

Aspirin use is associated with a higher rate of vitamin B12 deficiency in patients hospitalized with cardiovascular disease.
Abstract Title: Association of aspirin use with vitamin B12 deficiency (results of the BACH study).
Abstract Source: Am J Cardiol. 2004 Oct 1;94(7):975-7.
PMID: 15464695
Study Type: Human Study
Re: Aspirin
July 04, 2018 06:41PM
Carey - The mentioning of raising cholesterol undoubtedly came from the findings that those with higher cholesterol and aging... tend not to have the problems with Alzheimer's dementia that can be common with very low cholesterol levels.
The advocates for higher levels of the good cholesterol, HDL, have been indicating for several years now why 'cholesterol is not the enemy' but the good kind is essential for brain health... so rather than using the aspirin with its many other negative effects, cholesterol along with healthy fats in the diet are brain sparing.

Jackie
Re: Aspirin
July 04, 2018 07:14PM
Quote
Jackie
While it can provide relief from pain and certainly, if one thinks they may be having a stroke, some advocate for taking aspirin immediately. However, it’s important to be aware of the many studies indicating the risks of aspirin usage.

I don't know who advocates that but unless you have your own home CT scanner and can differentiate between an embolic and hemorrhagic stroke, taking an aspirin for a suspected stroke is a really bad idea. It won't do anything for an embolic stroke and may very well seal your fate for a hemorrhagic stroke. However, what is recommended and is standard practice in EMS and ERs is taking an aspirin immediately in response to a suspected heart attack.

No question that aspirin has risks and shouldn't be used for routine pain/fever relief (though for some arthritis sufferers it's necessary). These days aspirin is used almost solely for its antiplatelet properties, as I mentioned a few posts back. It has its place, but not as a household pain/fever reducer, and definitely not for stroke prevention with afib.
Re: Aspirin
July 04, 2018 07:19PM
Quote
Jackie
Carey - The mentioning of raising cholesterol undoubtedly came from the findings that those with higher cholesterol and aging... tend not to have the problems with Alzheimer's dementia that can be common with very low cholesterol levels.
The advocates for higher levels of the good cholesterol, HDL, have been indicating for several years now why 'cholesterol is not the enemy' but the good kind is essential for brain health... so rather than using the aspirin with its many other negative effects, cholesterol along with healthy fats in the diet are brain sparing.

Oh, okay, thanks. A bit of a leap there in subject material. I've long been convinced that the war on fats is the biggest man-made public health disaster of the 20th century.
Re: Aspirin
July 04, 2018 11:52PM
Patients taking aspirin before and after CABG surgery show reduced mortality risk. This is a current study, jackies appear to be older. Most meds can have problems even Eliquis. Stopping Coumadin caused me to have blood clots.


[www.news-medical.net]

liz
Re: Aspirin
July 04, 2018 11:59PM
Quote
Carey

I've long been convinced that the war on fats is the biggest man-made public health disaster of the 20th century.

"Cholesterol lowering drugs are BIG business. The pharmaceutical industry earns billions of dollars every year, and they are very clever to keep the big cholesterol myth alive."

"LDL transports cholesterol from the liver to the body. If your LDL is to low, you may be more vulnerable to infections, cancer and other diseases. Several studies around the world show that people with low LDL or low total cholesterol have higher mortality than people with normal or high cholesterol."

"This means eggs, butter, full-fat dairy products, nuts, coconut oil and meat have now been classified as *safe* and have been officially removed from the _nutrients of concern_ list."

[www.quora.com]
[www.action-inter.net]
Re: Aspirin
July 05, 2018 02:59AM
from Chris Kresser: [chriskresser.com]

Natural Alternatives:

Pycnogenol, "which is also referred to as pine bark extract, French maritime pine bark extract, at a dose of about 100 mg a day. It’s been shown to reduce platelet aggregation as effectively as aspirin without increasing the risk of bleeding, and it actually even has a prolonged action time, so it works over a longer period of time than aspirin does. You don’t have to take as much or take it as frequently."

policosanol. "The dose would be 20 mg per day, and studies have shown that that’s as effective as 100 mg of aspirin as a platelet aggregation inhibitor in terms of reducing the risk of thromboembolism. This was from a randomized clinical trial, and there are a few trials supporting policosanol for this use."


cod liver oil or fish oil, Omega 3 from fish (salmon, etc)
dark chocolate,herbs
Joe
Re: Aspirin
July 05, 2018 04:43AM
Wonder what increasing the Zeta potential does for platelet stickiness? It is supposed to separate red blood cells according to Dr Sinatra's observation under the microscope.
Re: Aspirin
July 05, 2018 07:11AM
Low Cholesterol contributes to dementia. Aspirin can easily be replaced by several supplements, but hey to each his own.
Re: Aspirin
July 05, 2018 10:14AM
Quote
hwkmn05
Aspirin can easily be replaced by several supplements, but hey to each his own.

What makes supplements better than aspirin? Aspirin is arguably every bit as "natural" as any "supplement," and it has very well known properties. It's also not counterfeited, nor contaminated with heavy metals and pesticides Chinese factories don't bother screening for in supplements.
Re: Aspirin
July 05, 2018 12:15PM
Quote
Carey
. It's also not counterfeited, nor contaminated with heavy metals and pesticides Chinese factories don't bother screening for in supplements.

Now Foods
3997 Reviews
Now Foods Reviews
4.7 (out of 5)

"Founded in 1968, Now Foods is one of the country's most respected names in healthy living supplements. Located in Bloomingdale, Illinois, Now's state-of-the art, 209,000 square-foot facility manufactures more than 900 unique items, all priced affordably"

Just bought some policosanol

Quote
Carey
and it has very well known properties

as listed above....



Edited 1 time(s). Last edit at 07/05/2018 12:22PM by jpeters.
Re: Aspirin
July 05, 2018 04:14PM
Quote
jpeters
"Founded in 1968, Now Foods is one of the country's most respected names in healthy living supplements. Located in Bloomingdale, Illinois, Now's state-of-the art, 209,000 square-foot facility manufactures more than 900 unique items, all priced affordably"

Just bought some policosanol

Just because it's manufactured in the US doesn't mean it's any better. Supplements don't have to meet the same dosage and purity standards that drugs do. Supplements are notorious for being counterfeited, contaminated and of wildly varying strengths.

And that still doesn't answer my primary question of what makes supplements better than aspirin.
Re: Aspirin
July 05, 2018 04:43PM
Carey, you can count on pharm to be pure and thinking of you.

" In 2014 Bayer bought MSD's consumer business, with brands such as Claritin, Coppertone and Dr. Scholl's. Its BayerCropscience business develops genetically modified crops and pesticides."

"Bayer was founded in Barmen in 1863. It was part of IG Farben, the world's largest chemical and pharmaceutical company, from 1925 to 1952, and became an independent company again after IG Farben was broken up by the Allies after World War II due to its collaboration with the Nazi regime."


Acquisition of Monsanto:
" March 21, 2018, the deal was approved by the European Union,[66][67] and it was approved in the United States on May 29, 2018.[68] The sale closed on June 7, 2018;[69] the Monsanto brand is discontinued, and all of its products are marketed under the Bayer name."

[en.wikipedia.org]



Edited 1 time(s). Last edit at 07/05/2018 04:45PM by jpeters.
Re: Aspirin
July 05, 2018 08:48PM
Quote
jpeters
Carey, you can count on pharm to be pure and thinking of you.

I expect nothing of the sort. I expect them to chase profits at all costs, including destroying lives if necessary. That's why the FDA and similar regulatory bodies exist in other countries.

What I expect is drug manufacturers to meet FDA manufacturing requirements, and the fact is that supplement manufacturers don't have to. You can easily find numerous examples of contaminated, counterfeited, mislabeled, and inaccurate dosing among supplements. You can't find the same among drugs.

I repeat my primary question a third time: What makes supplements better than aspirin?
Re: Aspirin
July 05, 2018 09:04PM
You can easily find numerous examples of contaminated, counterfeited, mislabeled, and inaccurate dosing among supplements.


How do we find these examples? It would be a good idea if someone would advise us which to avoid.
Maybe The Vitamin Shop could make recommendations.
Re: Aspirin
July 06, 2018 12:18AM
Quote
Carey



What I expect is drug manufacturers to meet FDA manufacturing requirements
I repeat my primary question a third time: What makes supplements better than aspirin?

[www.pbs.org]
“The virginity was lost in ’92,” said Dr. Jerry Avorn, a professor at Harvard Medical School. “Once you have that paying relationship, it creates a dynamic that’s not a healthy one.”

The side affects of aspirin are well documented, and have already been posted. You can do your own research regarding studies that support alternatives. Personally, I'd probably opt for some combination until I was absolutely sure. Here's one:

"Policosanol blunts Platelet Aggregation better than does Aspirin"

[heartfixer.com]


A frequent complaint I hear, is that generics are constantly changing their formula, so you can't get what used to work for you. $$$$$



Edited 2 time(s). Last edit at 07/06/2018 12:42AM by jpeters.
Re: Aspirin
July 06, 2018 01:13AM
Sorry, but one guy's quote and one study vs. 2000+ years of real world experience and a couple hundred years of scientific investigation doesn't do much for me. Aspirin was known to the ancient Egyptians, Hippocrates wrote about it, it's been known and used for thousands of years, but somehow now it's an evil drug? There are few drugs that mankind knows more about than aspirin. And the notion that Big Pharma is making big money off aspirin, or changing its formula, is just not realistic.
Re: Aspirin
July 06, 2018 02:44AM
Carey, getting a little off topic here. If you're getting a watchman, and you are told to take aspirin, that's what you take.
Okay? If I want to try to improve the outcome after looking at some studies by combining with a supplement, I'd be interested.
Re: Aspirin
July 06, 2018 06:17AM
Quote
Carey

Aspirin can easily be replaced by several supplements, but hey to each his own.

What makes supplements better than aspirin? Aspirin is arguably every bit as "natural" as any "supplement," and it has very well known properties. It's also not counterfeited, nor contaminated with heavy metals and pesticides Chinese factories don't bother screening for in supplements.
I could say Digitalis is natural also, but that flower can stop my heart.
H2O is a good start and Mag can possibly provide the same relief. Dont just blame the Asian crowd, plenty of that state side too.
I get most of my supplements from foods, but of course, thats another issue, if there is any food left in our foods. I guess Im puzzled by the aspirin debate here. I can believe the ER offering to heart attack patients, but does a standing dose really provide any appreciable benefit for afib or stroke risk?
Re: Aspirin
July 06, 2018 09:39PM
Quote
hwkmn05
debate here. I can believe the ER offering to heart attack patients, but does a standing dose really provide any appreciable benefit for afib or stroke risk?

No, it doesn't. It has its uses, but stroke prevention in afib isn't one of them. I don't think anyone said otherwise. It simply became the example of the drugs vs. supplements debate above.
Re: Aspirin
July 07, 2018 03:43AM
Quote
Carey
It simply became the example of the drugs vs. supplements debate above.

Supplement:

"something that completes or enhances something else when added to it."
Re: Aspirin
July 07, 2018 05:46AM
With all these modern wonderful meds, why are we bothering with cheap 2000 yr old salicylates?
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