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Re: What is normal for the abnormal?
June 29, 2018 10:51PM
Pradaxa and Eliquis have FDA approved reversal agents. Praxbind and Andexxa.
Re: What is normal for the abnormal?
June 29, 2018 11:20PM
It takes a 2 hour infusion of andoxanet alfa, significantly reversed by 92.7%. You had better be near a hospital that has this antidote. Coumadin's reversal agent is Vit. K.

liz
Re: What is normal for the abnormal?
June 30, 2018 01:15AM
I discussed the reversibility issue with my thrombosis pharmD... I think he said that there is some for Pradaxa, and it's expensive. The drug that was recently approved for some of the other blood thinners is not actually available yet... When it is, it is supposed be $27,000.

We'll see how problematic the INR is. I hit the goal of 2 today... Now to see how consistent I am. At least I'm lucky that the thrombosis clinic is just a quick little work break.
Clearly the blood thinners suck... A friends dog scratched my arm the other night... A few little scratches look pretty horrible on warfarin.)
Re: What is normal for the abnormal?
June 30, 2018 07:59AM
The first line of treatment for hemorrhage in an anticoagulated patient is simple plasma infusion until the drug wears off (12 hours or so). Reversal agents would only be used in cases where that wasn't fast enough.
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