Lumbrokinase for Clot Risk Prevention

For afibbers who are not yet required to use one of the prescription anticoagulants, we often recommend the fibrinolytic enzyme, Nattokinase ** which helps keep blood from hyperviscosity status. Because nattokinase is a soy-derived enzyme, people with soy sensitivities are not able to use it.

There is another fibrinolytic enzyme that has been used for years and is even more potent than nattokinase. I was gathering this data to share with a person interested in reducing stroke risk from hyperviscosity and thought I should also bring the topic up again for the many new members who aren’t yet required to use Rx blood thinners as a reminder there is an option to nattokinase. Using lumbrokinase, in addition to testing for all the viscosity markers, can certainly help keep people free of clot risk but the important thing to remember is do the appropriate testing so you know you are at safe levels and if not take steps to get those in line. See the links at the end for previous posts on the important testing as well.

When Garry F. Gordon, MD, DO, MD(H) of Payson, Arizona, well-known expert on chelation therapy, detoxification, anti-aging, alternative medicine, and energy medicine therapies was participating in his online FACT forum, he was a strong advocate for using lumbrokinase or Bolouke® for those who needed to manage hyperviscosity by natural means.

Following are some of the relevant clips I’ve gleaned and saved over the years on Boluoke/lumbrokinase along with links to various reports on this topic so those interested can do further research:


Lumbrokinase is a more potent enzyme preparation than nattokinase. One of the advantages of Boluoke® (lumbrokinase) is that it does not interfere with the clotting cascade, but instead, works by reducing fibrinogen and fibrin. Boluoke® does not affect INR or aPTT, thus is compatible with Coumadin® or heparin.

There are no known interactions between lumbrokinase and commonly used cardiovascular drugs, anti-hypertensives, or anti-cholesterol medications. We only caution doctors about using lumbrokinase with strong anti-platelets (such as Plavix® or Ticlid®), because there have been a few reports of nosebleeds when they are used together. This is probably because lumbrokinase also has an anti-platelet effect, and combining the medications may be too much in some patients (but this is not an absolute contra-indication).

Lumbrokinase has been used together with aspirin quite a few studies with no adverse reactions/interactions reported. However, the inherent increased risk of GI bleed is still present when taking aspirin. If your patient has not had a thromboembolism, then a starting dose of one cap TID is probably appropriate. You should then re-check the patient's blood viscosity or coagulation status after three to four weeks. If your patient has had previous thromboembolic conditions (especially recently), then a starting dose of two cap TID is more appropriate. Again, recheck the patient's viscosity or coagulation status in three to four weeks and adjust the dosage accordingly.

Dr. John Cline from Canada gave a talk at the Institute for Functional Medicine conference and said lumbrokinase was 200 times more potent than nattokinase.

However, since lumbrokinase is much stronger than nattokinase, it is not necessary to take both lumbrokinase and nattokinase. It makes more sense to take lumbrokinase and pure MK7 instead.

Martin Kwok, BSc, MSAOM, ND has written most prolifically on the enzyme, lumbrokinase marketed commercially as Bolouke… He says: When it comes to acute ischemic stroke, the enzyme with the most research is Boluoke (lumbrokinase). Its Phase I-III clinical trials are on exactly acute ischemic stroke. Lumbrokinase is also a much stronger fibrinolytic enzyme than serrapeptase.

Martin Kwok, ND
Richmond, BC

The May 2018 issue of Townsend Letter has this detailed report on Lumbrokinase.
[townsendletter.com]

Read here:

[aging-matters.com]

[bcenter.org]

[www.canadarna.com]

More research
[pdfs.semanticscholar.org]

[www.sersc.org] - this is the pdf…

[www.naturodoc.com]


Viscosity Risk Factors

Silent Inflammation
[www.afibbers.org]

Sticky, thick blood - Risk of Stroke and MI
[www.afibbers.org]

Clot Risk
[www.afibbers.org]


Jackie

** Refer to the post about reliable brands of Nattokinase that are labeled as the NSK-SD(R) and JKNA
as listed in the post at this link [www.afibbers.org]



Edited 2 time(s). Last edit at 12/22/2018 10:11AM by Jackie.

Excellent, thank you so much for putting that all together!

Thanks for all the info Jackie!

Also, the May 2018 issue of Townsend Letter: The Examiner for Alternative Medicine has a great article on lumbrokinase: Lumbrokinase – An Enzyme for More Than Just Circulatory Health!.

It points out that most of the research on lumbrokinase so far has been done by Korean and Chinese researchers (over 650 publications in the Chinese database vs. 65 in PubMed.)

More importantly, lumbrokinase (which is derived from ground-up earthworms) is a powerful fibrinolytic both through the plasminogen system and also independently from the plasminogen system. It inhibits PAI-1 activly and enhances t-PA activity. It not only promotes fibrinolysis but also fibrinogenesis; this bi-directional "balancing" mechanism may have contributed to its great safety record.

When compared capsule-to-capsule. Lumbrokinase's enzymatic (t-PA) activity is 36 times more powerful than nattokinase and 300 times more than serrapeptidase.

Clinical applications may include not only ischemic stroke, but also coronary artery disease, oncology and chronic biofilm associated infections. It may improve diabetic nephropathy and neuropathy.

The same issue of Townsend is very informative on heart issues and has several relevant articles:

- Hypertension Becomes a Much Bigger Threat

- Testosterone's Role in Cardiovascular Health: A Review of the Literature

- Berberine: New Research on Mechanisms Via Which This Alkaloid May Impact Metabolic and Cardiovascular Health

all available for reading on the Townsend website (see link above).

Thank you for all this information!